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TAG Degradation Platforms Small Molecule
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6605/5

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Bio-Techne Corporation
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Key Product Details

Description: Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation
Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥98% (HPLC)
Molecular Weight: 1049.18

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  • dTAG-13 treatment of FKBP tagged over expressed protein in glioma cell lines
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Glioma
    Assayed the degradation of FKBP-tagged-protein with HA tag in glioma cells using dTAG-13 at 500nM concentration for 0h, 4h, 6h and 24h time intervals. Untransfected cells has no HA signal and in transfected cells with dTAG-13 treatment lead to complete degradation of FKBP-tagged-protein in whole cell lysates
    dTAG-13 Serum 6605
  • Knockdown of FKBP-tagged Chromatin Protein
    Name: Sam Weeks
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: mESC
    Assayed different dTag concentrations (50nm, 250nm, 500nm) for the knockdown of a FKBP-tagged chromatin-bound protein (180kDa). Whole cell lysate (RIPA) revealed no change to WT cells (150kDa) and considerable knockdown in all conditions after just an hour of treatment.
    dTAG-13 Serum 6605
  • Works better than expected
    Name: Abderhman Abuhashem
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: E14 (mouse Embryonic Stem cells)
    Used dTAG-13 to degrade a transgene tagged with FKBM12-F36V and HA tags to visualize the protein.
    This is a western blot probed for HA tag to track degradation. All samples are treated with 500nM dTAG-13. Lanes are: 1) parental cell line, 2) control (no treatment), 3) 30 mins of treatment, 4) 1hr of treatment, 5) 2hrs of treatment, 6) 4hrs of treatment, 7) 6hrs of treatment. The constructs, as shown by the western, was degraded almost entirely (>98% quantified), within 30 mins. I have tested batch 2 of this product at conc. as low as 50nM and still just as effective. No apparent toxicity to cells. Extremely satisfied.
    dTAG-13 Serum 6605

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