dTAG-13-NEG

Name: dTAG-13-NEG
Brand: Tocris Bioscience
SKU: 6916

Tocris Bioscience a Bio-Techne Brand

Catalog # 6916

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Key Product Details

Description:	Negative control for dTAG-13 (Cat. No. 6605)
Chemical Name:	1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity:	≥97% (HPLC)
Molecular Weight:	1063.19

View Full Technical Details for dTAG-13-NEG

Biological Activity for dTAG-13-NEG

dTAG-13-NEG is a negative control for dTAG-13 (Cat. No. 6605).

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for dTAG-13-NEG

M. Wt	1063.19
Formula	C₅₈H₇₀N₄O₁₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
InChi Key	ZKVNXENIWGNDDO-SKTJQTJUSA-N
Smiles	CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC=C3OCC(NCCCCCCOC4=CC=CC(C(N5C6CCC(N(C)C6=O)=O)=O)=C4C5=O)=O)CCC7=CC(OC)=C(C=C7)OC)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for dTAG-13-NEG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	106.32	100
	ethanol	21.26	20

Preparing Stock Solutions for dTAG-13-NEG

The following data is based on the product molecular weight 1063.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.94 mL	4.70 mL	9.41 mL
5 mM	0.19 mL	0.94 mL	1.88 mL
10 mM	0.09 mL	0.47 mL	0.94 mL
50 mM	0.02 mL	0.09 mL	0.19 mL

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Reconstitution Calculator

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References for dTAG-13-NEG

References are publications that support the biological activity of the product.

Nabet Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat.Commun. 2020 PMID: 32948771
Nabet The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 2018 PMID: 29581585

Citations for dTAG-13-NEG

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dTAG-13-NEG

Tocris Bioscience a Bio-Techne Brand

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