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Active Degraders: Small Molecules and Peptides

Degraders are a way to knock down target proteins within cells. They are made up of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. These hybrid molecules induce selective, proteasome-dependent degradation of target proteins. Degraders be also used to investigate the downstream effects of protein knockdown or to interfere with specific signaling pathways.

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84 results for "Active Degraders Small Molecules and Peptides" in Products

Active Degraders: Small Molecules and Peptides

Degraders are a way to knock down target proteins within cells. They are made up of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. These hybrid molecules induce selective, proteasome-dependent degradation of target proteins. Degraders be also used to investigate the downstream effects of protein knockdown or to interfere with specific signaling pathways.

Products:

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84 results for "Active Degraders Small Molecules and Peptides" in Products

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Potent TANK-binding kinase 1 (TBK1) PROTAC®

Selective and potent TAG Degrader for auxin-inducible degron 2 system

Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

(+)-JQ1 based PROTAC® with selectivity for BRD4

Selective JAK2 Degrader (PROTAC®)

Potent and selective androgen receptor Degrader (PROTAC®)

Selective peptide-based β-catenin Degrader (PROTAC®)

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo

SRC-1 peptide-based Degrader (PROTAC®); active in vivo

Mitochondrial targeting AUTAC Degrader

Polycomb repressive complex 2 (PRC2) Degrader (PROTAC®)

Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR

Potent and selective Wee1 Degrader (PROTAC®)

Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)

Potent BRAF Degrader (PROTAC®

c-MET PROTAC®; also degrades exon-14-deleted c-MET

Degrader of MTH1 fusion proteins for use within the aTAG system

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