dBRD9-A

Name: dBRD9-A
Brand: tocris
SKU: 6943

Catalog # 6943

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

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Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	Potent BRD9 Degrader (PROTAC^®)
Chemical Name:	2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	779.88

View Full Technical Details for dBRD9-A

Technical Data
Citations / Reviews

Biological Activity

Potent BRD9 Degrader (PROTAC^®). Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data

M. Wt	779.88
Formula	C₄₂H₄₉N₇O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2170679-42-0
PubChem ID	139370810
InChi Key	ZDINQSNMYRVAGP-UHFFFAOYSA-N
Smiles	COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCCCCCCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	77.99	100
	ethanol	7.8	10

Preparing Stock Solutions

The following data is based on the product molecular weight 779.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.28 mL	6.41 mL	12.82 mL
5 mM	0.26 mL	1.28 mL	2.56 mL
10 mM	0.13 mL	0.64 mL	1.28 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Brien Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife 2018 PMID: 30431433