dBRD9-A
Tocris Bioscience, part of Bio-Techne | Catalog # 6943
Potent BRD9 Degrader (PROTAC®)
Product Description
dBRD9-A is a potent BRD9 Degrader (PROTAC®). Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model. BRD9 antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # NBP3-14730.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license
Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
779.88
Formula
C42H49N7O8
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)acetamide
CAS Number
2170679-42-0
PubChem ID
139370810
InChI Key
ZDINQSNMYRVAGP-UHFFFAOYSA-N
SMILES
COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCCCCCCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 77.99 | 100 | |
| Ethanol | 7.8 | 10 |
Preparing Stock Solutions
for dBRD9-A
The following data is based on the product molecular weight 779.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.28 mL | 6.41 mL | 12.82 mL |
| 5 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 10 mM | 0.13 mL | 0.64 mL | 1.28 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.26 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brien Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife 2018 PMID: 30431433
Product Specific Notices for dBRD9-A
For research use only
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