TL 12-186

Name: TL 12-186
Brand: tocris
SKU: 6524

Catalog # 6524

Datasheet / COA / SDS

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Bio-Techne Corporation

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$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	Multikinase Degrader (PROTAC^®)
Chemical Name:	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	931.46

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Biological Activity

Degrader (PROTAC^®) comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines.

Negative control TL 13-27 (Cat. No. 6525) is also available.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M. Wt	931.46
Formula	C₄₄H₅₁ClN₁₀O₉S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250025-88-6
PubChem ID	134812843
InChi Key	YNGWQHGVASHCBK-UHFFFAOYSA-N
Smiles	O=C1C(CCC(N1)=O)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	93.15	100

Preparing Stock Solutions

The following data is based on the product molecular weight 931.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.07 mL	5.37 mL	10.74 mL
5 mM	0.21 mL	1.07 mL	2.15 mL
10 mM	0.11 mL	0.54 mL	1.07 mL
50 mM	0.02 mL	0.11 mL	0.21 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Huang A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 2018 PMID: 29129717