TL 12-186
Tocris Bioscience, part of Bio-Techne | Catalog # 6524
Multikinase Degrader (PROTAC®)
Product Description
TL 12-186 is a degrader (PROTAC®) comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines.Negative control TL 13-27 (Cat. No. 6525) is also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
931.46
Formula
C44H51ClN10O9S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
CAS Number
2250025-88-6
PubChem ID
134812843
InChI Key
YNGWQHGVASHCBK-UHFFFAOYSA-N
SMILES
O=C1C(CCC(N1)=O)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 93.15 | 100 |
Preparing Stock Solutions
for TL 12-186
The following data is based on the product molecular weight 931.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 5 mM | 0.21 mL | 1.07 mL | 2.15 mL |
| 10 mM | 0.11 mL | 0.54 mL | 1.07 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Huang A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 2018 PMID: 29129717
Product Specific Notices for TL 12-186
For research use only
Loading...
Loading...