TL 13-27
Tocris Bioscience, part of Bio-Techne | Catalog # 6525
Negative control for TL 12-186 (Cat. No. 6524)
Key Product Details
Description
Negative control for TL 12-186 (Cat. No. 6524)
Product Description
TL 13-27 is a negative control for TL 12-186 (Cat. No. 6524). Demonstrates no kinase degradation in vitro.Product Specifications
Molecular Weight
917.48
Formula
C44H53ClN10O8S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
CAS Number
2250025-90-0
PubChem ID
134812844
InChI Key
DOOUFCVVMSZNOA-UHFFFAOYSA-N
SMILES
O=C1C(CCCN1)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 91.75 | 100 |
Preparing Stock Solutions
for TL 13-27
The following data is based on the product molecular weight 917.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.09 mL | 5.45 mL | 10.90 mL |
| 5 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 10 mM | 0.11 mL | 0.54 mL | 1.09 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Huang A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 2018 PMID: 29129717
Product Specific Notices for TL 13-27
For research use only
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