Pomalidomide
Tocris Bioscience, part of Bio-Techne | Catalog # 6302
Cereblon binder; also TNF-α inhibitor and antiangiogenic
Key Product Details
Description
Cereblon binder; also TNF-α inhibitor and antiangiogenic
Product Description
Pomalidomide is a potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic. Promotes degradation of transcription factor SALL4.Product Specifications
Molecular Weight
273.24
Formula
C13H11N3O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS Number
19171-19-8
PubChem ID
134780
InChI Key
UVSMNLNDYGZFPF-UHFFFAOYSA-N
SMILES
NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.32 | 100 |
Preparing Stock Solutions
for Pomalidomide
The following data is based on the product molecular weight 273.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.66 mL | 18.30 mL | 36.60 mL |
| 5 mM | 0.73 mL | 3.66 mL | 7.32 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chamberlain Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett. 2019 PMID: 31857833
- Donovan Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 2018 PMID: 30067223
- Winter Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 PMID: 25999370
- Lai Modular PROTAC design for the degradation of oncogenic BCR-ABL. Angew.Chem.Int.Ed.Engl. 2016 PMID: 26593377
- Nanthakumar Dissecting fibrosis: therapeutic insights from the small-molecule toolbox. Nat.Rev.Drug.Discov. 2015 PMID: 26338155
- Lohbeck & Miller Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 2016 PMID: 27687673
Product Specific Notices for Pomalidomide
For research use only
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