41 results for "Ubiquitin Ligase (E3) Inhibitors" in Products

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Ubiquitin Ligase (E3) Inhibitors

Nutlin-3
Catalog #: 3984
(1)
Citations (36)
Product Documents
Images (1)

MDM2 antagonist; inhibits MDM2-p53 interaction

Chemical Name:
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Purity:
≥98%
MDM2 antagonist; inhibits MDM2-p53 interaction
Catalog #
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3984/10
3984/50
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MZ 1
Catalog #: 6154
Citations (19)
Product Documents
Images (2)

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

Chemical Name:
(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:
≥98%
Application of MZ 1 in HeLa Cells
(2)
Catalog #
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Qty
6154/5
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Apcin
Catalog #: 5747
Citations (16)
Product Documents
Images (1)

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Chemical Name:
3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
Purity:
≥98%
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
Catalog #
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5747/10
5747/50
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Nutlin 3a
Catalog #: 6075
Citations (23)
Product Documents
Images (1)

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

Chemical Name:
4-[[(4S,5R)-4,5-bis(4-Chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Purity:
≥97%
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
Catalog #
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6075/25
6075/5
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Lenalidomide
Catalog #: 6305
(1)
Citations (9)
Product Documents
Images (1)

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name:
3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity:
≥98%
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Catalog #
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6305/100
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CSN5i-3
Catalog #: 7089
Citations (2)
Product Documents
Images (2)

Potent and selective CSN5 (COP9 signalosome) inhibitor

Chemical Name:
3-(Difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,10-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide
Purity:
≥98%
Novartis vs Bio-Techne batch comparison for CSN5i-3
(2)
Catalog #
Availability
Size / Price
Qty
7089/2
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HLI 373
Catalog #: 3503
Citations (4)
Product Documents
Images (1)

Hdm2 inhibitor; activates p53-dependent transcription

Chemical Name:
5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
Purity:
≥98%
Hdm2 inhibitor; activates p53-dependent transcription
Catalog #
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3503/10
3503/50
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SMER 3
Catalog #: 4375
Citations (5)
Product Documents
Images (1)

Selective inhibitor of E3 ubiquitin ligase

Chemical Name:
9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Purity:
≥98%
Selective inhibitor of E3 ubiquitin ligase
Catalog #
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4375/50
4375/10
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SZL P1-41
Catalog #: 5076
Citations (5)
Product Documents
Images (1)

Selective Skp2 inhibitor; suppresses E3 ligase activity

Chemical Name:
3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Purity:
≥98%
Selective Skp2 inhibitor; suppresses E3 ligase activity
Catalog #
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5076/50
5076/10
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GS 143
Catalog #: 5636
Citations (4)
Product Documents
Images (1)

β-TrCP1 ligase inhibitor

Chemical Name:
4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Purity:
≥98%
β-TrCP1 ligase inhibitor
Catalog #
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5636/10
5636/50
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VH 298
Catalog #: 6156
Citations (11)
Product Documents
Images (1)

High-affinity inhibitor of VHL

Chemical Name:
(2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:
≥98%
High-affinity inhibitor of VHL
Catalog #
Availability
Size / Price
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6156/10
6156/50
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Pomalidomide
Catalog #: 6302
Citations (5)
Product Documents
Images (1)

Cereblon binder; also TNF-α inhibitor and antiangiogenic

Chemical Name:
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:
≥98%
Cereblon binder; also TNF-α inhibitor and antiangiogenic
Catalog #
Availability
Size / Price
Qty
6302/10
6302/50
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dBET1
Catalog #: 6327
Citations (4)
Product Documents
Images (1)

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name:
(6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:
≥98%
(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
Catalog #
Availability
Size / Price
Qty
6327/5
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Indisulam
Catalog #: 6782
Citations (1)
Product Documents
Images (1)

Molecular glue; pre-mRNA splicing modulator

Chemical Name:
N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
Purity:
≥98%
Molecular glue; pre-mRNA splicing modulator
Catalog #
Availability
Size / Price
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6782/25
6782/5
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CRBN-6-5-5-VHL
Catalog #: 6948
Product Documents
Images (2)

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Chemical Name:
(2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:
≥96%
Application of CRBN-6-5-5-VHL in MM1S cells for CRBN-6-5-5-VHL
(2)
Catalog #
Availability
Size / Price
Qty
6948/5
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RITA
Catalog #: 2443
Citations (11)
Product Documents
Images (1)

MDM2-p53 interaction inhibitor

Alternate Names:
NSC 652287
Chemical Name:
5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
Purity:
≥97%
MDM2-p53 interaction inhibitor
Catalog #
Availability
Size / Price
Qty
2443/1
2443/10
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PRT 4165
Catalog #: 5047
Citations (14)
Product Documents
Images (1)

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

Chemical Name:
2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione
Purity:
≥98%
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
Catalog #
Availability
Size / Price
Qty
5047/10
5047/50
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SP 141
Catalog #: 5332
Citations (5)
Product Documents
Images (1)

High affinity MDM2 inhibitor

Chemical Name:
6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Purity:
≥98%
High affinity MDM2 inhibitor
Catalog #
Availability
Size / Price
Qty
5332/50
5332/10
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Heclin
Catalog #: 5433
Citations (13)
Product Documents
Images (1)

HECT E3 ubiquitin ligase inhibitor

Chemical Name:
N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity:
≥98%
HECT E3 ubiquitin ligase inhibitor
Catalog #
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5433/10
5433/50
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cis VH 298
Catalog #: 6157
Product Documents
Images (1)

Negative control for VH 298

Chemical Name:
(2S,4S)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:
≥98%
Negative control for VH 298
Catalog #
Availability
Size / Price
Qty
6157/10
Bulk Order

AT 1
Catalog #: 6356
(1)
Citations (3)
Product Documents
Images (1)

(+)-JQ1 based PROTAC® with selectivity for BRD4

Chemical Name:
(2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide
Purity:
≥98%
(+)-JQ1 based PROTAC® with selectivity for BRD4
Catalog #
Availability
Size / Price
Qty
6356/5
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CM 11
Catalog #: 6416
Citations (1)
Product Documents
Images (1)

Homo-PROTAC® for self-degradation of pVHL30

Chemical Name:
N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
Purity:
≥98%
Homo-PROTAC® for self-degradation of pVHL30
Catalog #
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Size / Price
Qty
6416/5
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TL 12-186
Catalog #: 6524
Citations (2)
Product Documents
Images (1)

Multikinase Degrader (PROTAC®)

Chemical Name:
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Purity:
≥98%
Multikinase Degrader (PROTAC®)
Catalog #
Availability
Size / Price
Qty
6524/5
Bulk Order

TL 13-27
Catalog #: 6525
Citations (1)
Product Documents
Images (1)

Negative control for TL 12-186 (Cat. No. 6524)

Chemical Name:
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
Purity:
≥98%
Negative control for TL 12-186 (Cat. No. 6524)
Catalog #
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Size / Price
Qty
6525/5
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Idasanutlin
Catalog #: 6904
Citations (2)
Product Documents
Images (1)

Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

Chemical Name:
4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid
Purity:
≥98%
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
Catalog #
Availability
Size / Price
Qty
6904/10
6904/50
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