SP 141
Tocris Bioscience, part of Bio-Techne | Catalog # 5332
High affinity MDM2 inhibitor
Key Product Details
Description
High affinity MDM2 inhibitor
Product Description
SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.Product Specifications
Molecular Weight
324.38
Formula
C22H16N2O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
CAS Number
1253491-42-7
PubChem ID
59620153
InChI Key
AABFWJDLCCDJJN-UHFFFAOYSA-N
SMILES
COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.44 | 100 | |
| Ethanol | 32.44 | 100 |
Preparing Stock Solutions
for SP 141
The following data is based on the product molecular weight 324.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 2014 PMID: 25271708
Product Specific Notices for SP 141
For research use only
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