RITA

Tocris Bioscience, part of Bio-Techne | Catalog # 2443

MDM2-p53 interaction inhibitor
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Key Product Details

Description

MDM2-p53 interaction inhibitor

Alternative Names

NSC 652287

View all p53 Activators »

Product Description

RITA is an anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.

Product Specifications

Molecular Weight

292.37

Formula

C14H12O3S2

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol

CAS Number

213261-59-7

PubChem ID

374536

InChI Key

KZENBFUSKMWCJF-UHFFFAOYSA-N

SMILES

OCC1=CC=C(S1)C1=CC=C(O1)C1=CC=C(CO)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.23 100
Ethanol 7.31 25

Preparing Stock Solutions for RITA

The following data is based on the product molecular weight 292.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.10 mL 34.20 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for RITA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RITA

For research use only

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