Nutlin-3
Tocris Bioscience, part of Bio-Techne | Catalog # 3984
MDM2 antagonist; inhibits MDM2-p53 interaction
Key Product Details
Description
MDM2 antagonist; inhibits MDM2-p53 interaction
Product Description
Nutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.Licensing Information
Sold under license from F. Hoffmann-La Roche Ltd.Product Specifications
Molecular Weight
581.49
Formula
C30H30Cl2N4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
CAS Number
548472-68-0
PubChem ID
16755649
InChI Key
BDUHCSBCVGXTJM-IZLXSDGUSA-N
SMILES
ClC1=CC=[C@@]([C@@H]3[C@@H](N(C(N5CC(NCC5)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N3)[C@]2=CC=C(Cl)C=C2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.15 | 100 | |
| Ethanol | 58.15 | 100 |
Preparing Stock Solutions
for Nutlin-3
The following data is based on the product molecular weight 581.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.72 mL | 8.60 mL | 17.20 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.72 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Vassilev In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004 PMID: 14704432
Product Specific Notices for Nutlin-3
For research use only
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