SZL P1-41

Product Description

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Solubility

Preparing Stock Solutions for SZL P1-41

The following data is based on the product molecular weight 420.52

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.89 mL	59.45 mL	118.90 mL
1 mM	2.38 mL	11.89 mL	23.78 mL
2 mM	1.19 mL	5.95 mL	11.89 mL
10 mM	0.24 mL	1.19 mL	2.38 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chan Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 2013 PMID: 23911321