Lenalidomide

Tocris Bioscience, part of Bio-Techne | Catalog # 6305

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
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Key Product Details

Description

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

View all Ubiquitin Ligase (E3) Inhibitors »

Product Description

Lenalidomide is a thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4CRBN. Also TNF-α inhibitor and angiogenesis inhibitor. Promotes degradation of transcription factor SALL4.

Product Specifications

Molecular Weight

259.26

Formula

C13H13N3O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione

CAS Number

191732-72-6

PubChem ID

216326

InChI Key

GOTYRUGSSMKFNF-UHFFFAOYSA-N

SMILES

NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.93 100

Preparing Stock Solutions for Lenalidomide

The following data is based on the product molecular weight 259.26

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.29 mL 38.57 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Lenalidomide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Lenalidomide

For research use only

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