Lenalidomide

Name: Lenalidomide
Brand: Tocris Bioscience
SKU: 6305
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 6305

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Key Product Details

Description:	Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Chemical Name:	3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	259.26

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Biological Activity for Lenalidomide

Lenalidomide is a thalidomide analog. Immune modulatory drug and cereblon binding compound. Induces ubiquitination and degradation of casein kinase (CK) 1α by the E3 ubiquitin ligase CRL4^CRBN. Also TNF-α inhibitor and angiogenesis inhibitor. Promotes degradation of transcription factor SALL4.

Compound Libraries for Lenalidomide

Lenalidomide is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Lenalidomide

M. Wt	259.26
Formula	C₁₃H₁₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	191732-72-6
PubChem ID	216326
InChi Key	GOTYRUGSSMKFNF-UHFFFAOYSA-N
Smiles	NC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lenalidomide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.93	100

Preparing Stock Solutions for Lenalidomide

The following data is based on the product molecular weight 259.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.86 mL	19.29 mL	38.57 mL
5 mM	0.77 mL	3.86 mL	7.71 mL
10 mM	0.39 mL	1.93 mL	3.86 mL
50 mM	0.08 mL	0.39 mL	0.77 mL

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References for Lenalidomide

References are publications that support the biological activity of the product.

Chamberlain Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett. 2019 PMID: 31857833
Donovan Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 2018 PMID: 30067223
Petzold Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 2016 PMID: 26909574
Krönke Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 2015 PMID: 26131937

Citations for Lenalidomide

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Lenalidomide as Ikaros inhibitor

Name: Binod G C

Species: Human

Cell Line/Tissue: Ba/F

Lenalidomide was used to inhibit Ikaros to examine target gene expression. 2um concentration was used.

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Product Documents for Lenalidomide

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Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.