SJ 1008066

Tocris Bioscience, part of Bio-Techne | Catalog # 7542

MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction
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Key Product Details

Description

MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction

View all Ubiquitin Ligase (E3) Inhibitors »

Product Description

SJ 1008066 is a cell permeable inhibitor of testis-restricted melanoma antigen protein MAGE-A11 (IC50 = 0.13 μM). SJ 1008066 binds to the MAGE homology domain (MHD) and disrupts MAGE-A11:PCF11 interaction. SJ1008066 exhibits no effect on MAGE-A3:AMPKα1 or MAGE-F1:MMS19 interactions in TR-FRET and cell lysate pulldown assays.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Product Specifications

Molecular Weight

330.44

Formula

C21H22N4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N1-((1H-Indol-5-yl)methyl)-N3-(quinolin-4-yl)propane-1,3-diamine

CAS Number

2758867-71-7

PubChem ID

162444676

InChI Key

UMJWTJVGTTUEQK-UHFFFAOYSA-N

SMILES

C12=C(C=CC=C2)C(NCCCNCC3=CC4=C(C=C3)NC=C4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.04 100

Preparing Stock Solutions for SJ 1008066

The following data is based on the product molecular weight 330.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.30 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.30 mL 0.61 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for SJ 1008066

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJ 1008066

For research use only

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