TRAIL R2/TNFRSF10B Products
TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.
TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.
26 results for "TRAIL R2/TNFRSF10B" in Products
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TRAIL R2/TNFRSF10B Products
TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.
TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.
26 results for "TRAIL R2/TNFRSF10B" in Products
Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
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Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
Contains 8 membranes - each spotted in duplicate with 21 different apoptosis antibodies
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Functional Assay, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | CyTOF-ready, Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #118929 |
Applications : | Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Flow Cytometry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #71903 |
Applications : | Functional Assay |
Source : | Sf 21 (baculovirus) |
Accession # : | Q6GSD9 |
Applications : | Bioactivity |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | Flow Cytometry |
Source : | CHO |
Accession # : | AAH01281.1 |
Applications : | Bioactivity |
Clonality : | Monoclonal |
Host : | Mouse IgG2a Clone #603307 |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #71908 |
Applications : | Flow Cytometry |