Skip to main content

TRAIL R2/TNFRSF10B: Antibodies

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.

TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.

211 results for "TRAIL R2/TNFRSF10B Primary Antibodies" in Products

Back to Search Results
Apply

Search

TRAIL R2/TNFRSF10B: Antibodies

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.

TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.

211 results for "TRAIL R2/TNFRSF10B Primary Antibodies" in Products

WB, Flow
Catalog #: FAB6311S
Flow
Catalog #: FAB6311T
Flow
Catalog #: FAB6311V
Flow
Catalog #: FAB6311U
Flow
WB, AgAct
Flow, CyTOF-ready
WB
WB, Flow, CyTOF-ready, Neut
Flow
Flow, ICC/IF, IHC, WB
IHC, WB
B/N, Flow, ICC/IF, IHC, IP
Flow, IHC
ELISA, Flow, Func
ELISA, Flow

Recombinant Monoclonal Antibody

ELISA, Flow, Func, IP
Results Per Page
5 10 25 50
/ 9