18 results for "Methyltransferase Inhibitors Small Molecules and Peptides" in Products
Methyltransferase Inhibitors: Small Molecules and Peptides
Protein Arginine methyltransferases, or PRMTs, are a family of enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine residues on histones. PRMTs belong to the histone methyltransferase group of enzymes, which also includes lysine methyltransferases. They are also closely related in biological activity to the DNA methyltransferases and are ubiquitously expressed. Histone methylation of arginine residues occurs predominantly on histones H2A, H3 and H4, ...
DNA methyltransferase inhibitor
| Alternate Names: | 2'-Deoxy-5-azacytidine,5-Aza-2'-deoxycytidine,NSC 127716 |
| Chemical Name: | 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one |
| Purity: | ≥98% (HPLC) |
DNA methyltransferase inhibitor
| Chemical Name: | 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one |
| Purity: | ≥98% (HPLC) |
Non-nucleoside DNA methyltransferase inhibitor
| Chemical Name: | N-Phthalyl-L-tryptophan |
| Purity: | ≥98% (HPLC) |
Selective ASH1L histone methyltransferase inhibitor
| Chemical Name: | N-[[3-[3-(Aminothioxomethyl)phenyl]-1-[1-[(trifluoromethyl)sulfonyl]-4-piperidinyl]-1H-indol-6-yl]methyl]-1-methyl-3-azetidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective PRMT 4 inhibitor
| Chemical Name: | N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide |
| Purity: | ≥98% (HPLC) |
Potent and selective SETD7 inhibitor
| Chemical Name: | 8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride |
| Purity: | ≥97% (HPLC) |
Highly potent DOT1L inhibitor
| Chemical Name: | 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
Potent and selective type I PRMT inhibitor
| Chemical Name: | N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent WDR5/MLL interaction inhibitor
| Chemical Name: | 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate |
| Purity: | ≥95% (HPLC) |
Potent and selective PRMT5 inhibitor
| Chemical Name: | N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective EED inhibitor
| Chemical Name: | N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine |
| Purity: | ≥98% (HPLC) |
SUV39H1 inhibitor
| Chemical Name: | (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone |
| Purity: | ≥95% (HPLC) |
Potent and selective allosteric inhibitor of PRMT3
| Chemical Name: | 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea |
| Purity: | ≥98% (HPLC) |
Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
| Chemical Name: | 8-Fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride |
| Purity: | ≥97% (HPLC) |
Negative control of SGC 707 (Cat. No. 5367)
| Chemical Name: | N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea |
| Purity: | ≥98% (HPLC) |
Selective PRMT5 Degrader (PROTAC®)
| Chemical Name: | N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide |
| Purity: | ≥98% (HPLC) |
WDR5 antagonist
| Chemical Name: | 3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester |
| Purity: | ≥98% (HPLC) |
High affinity and selective WDR5 antagonist
| Chemical Name: | N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide |
| Purity: | ≥98% (HPLC) |
