SGC 707

Name: SGC 707
Brand: Tocris Bioscience
SKU: 5367

Tocris Bioscience, part of Bio-Techne | Catalog # 5367

Citations (1)

COA / SDS

Potent and selective allosteric inhibitor of PRMT3

Key Product Details

Description:	Potent and selective allosteric inhibitor of PRMT3
Chemical Name:	1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea
Purity:	≥98% (HPLC)
Molecular Weight:	298.34

View Full Technical Details for SGC 707

Technical Data
Citations

Biological Activity for SGC 707

SGC 707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC₅₀ = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. Decreases H4R3me2a levels in HEK293 cells in vitro.

Negative control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 707 probe summary on the SGC website.

Compound Libraries for SGC 707

SGC 707 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC 707 is reviewed on the chemical probes website.

Technical Data for SGC 707

M. Wt	298.34
Formula	C₁₆H₁₈N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1687736-54-4
PubChem ID	90642938
InChi Key	DMIDPTCQPIJYFE-UHFFFAOYSA-N
Smiles	O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC 707

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	29.83	100
	DMSO	29.83	100

Preparing Stock Solutions for SGC 707

The following data is based on the product molecular weight 298.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.70 mL
10 mM	0.34 mL	1.68 mL	3.35 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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Reconstitution Calculator

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References for SGC 707

References are publications that support the biological activity of the product.

Scheer A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 2019 PMID: 30604761
Kaniskan A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl 2015 PMID: 25728001