MM 102
Tocris Bioscience, part of Bio-Techne | Catalog # 5307
Potent WDR5/MLL interaction inhibitor
Key Product Details
Description
Potent WDR5/MLL interaction inhibitor
Product Description
MM 102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.Product Specifications
Molecular Weight
783.83
Formula
C35H49F2N7O4.CF3CO2H
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate
CAS Number
1883545-52-5
PubChem ID
71520620
InChI Key
ZRKTWBXVGMHWHM-YCBFMBTMSA-N
SMILES
O=C(NC(C2=CC=C(F)C=C2)C1=CC=C(F)C=C1)C3(CCCC3)NC([C@@H](NC(C(CC)(CC)NC(C(C)C)=O)=O)CCCNC(N)=N)=O.OC(C(F)(F)F)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 66.98 | 100 |
Preparing Stock Solutions
for MM 102
The following data is based on the product molecular weight 783.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.28 mL | 6.38 mL | 12.76 mL |
| 5 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 10 mM | 0.13 mL | 0.64 mL | 1.28 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.26 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Karatas High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc. 2013 PMID: 23210835
Product Specific Notices for MM 102
For research use only
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