MM 102

Name: MM 102
Brand: Tocris Bioscience
SKU: 5307

Tocris Bioscience, part of Bio-Techne | Catalog # 5307

Citations (8)

COA / SDS

Potent WDR5/MLL interaction inhibitor

Key Product Details

Description:	Potent WDR5/MLL interaction inhibitor
Chemical Name:	1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate
Purity:	≥95% (HPLC)
Molecular Weight:	783.83

View Full Technical Details for MM 102

Technical Data
Citations

Biological Activity for MM 102

MM 102 is a potent WDR5/MLL interaction inhibitor (IC₅₀ = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.

Compound Libraries for MM 102

MM 102 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for MM 102

M. Wt	783.83
Formula	C₃₅H₄₉F₂N₇O₄.CF₃CO₂H
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1883545-52-5
PubChem ID	71520620
InChi Key	ZRKTWBXVGMHWHM-YCBFMBTMSA-N
Smiles	O=C(NC(C2=CC=C(F)C=C2)C1=CC=C(F)C=C1)C3(CCCC3)NC([C@@H](NC(C(CC)(CC)NC(C(C)C)=O)=O)CCCNC(N)=N)=O.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MM 102

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	66.98	100

Preparing Stock Solutions for MM 102

The following data is based on the product molecular weight 783.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.28 mL	6.38 mL	12.76 mL
5 mM	0.26 mL	1.28 mL	2.55 mL
10 mM	0.13 mL	0.64 mL	1.28 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

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References for MM 102

References are publications that support the biological activity of the product.

Karatas High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc. 2013 PMID: 23210835