MS 023 dihydrochloride

Name: MS 023 dihydrochloride
Brand: Tocris Bioscience
SKU: 5713

Tocris Bioscience a Bio-Techne Brand

Catalog # 5713

Citations (3)

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Key Product Details

Description:	Potent and selective type I PRMT inhibitor
Chemical Name:	N¹-Methyl-N¹-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	360.32

View Full Technical Details for MS 023 dihydrochloride

Biological Activity for MS 023 dihydrochloride

MS 023 dihydrochloride is a potent and selective type I PRMT inhibitor (IC₅₀ values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro. Also inhibits and reduces TGF-β-activated kinase 1 expression and protein levels.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.

Technical Data for MS 023 dihydrochloride

M. Wt	360.32
Formula	C₁₇H₂₅N₃O.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1992047-64-9
PubChem ID	121513886
InChi Key	HCNXCUFNZWGILO-UHFFFAOYSA-N
Smiles	CC(C)OC1=CC=C(C2=CNC=C2CN(CCN)C)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 023 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	36.03	100
	DMSO	36.03	100

Preparing Stock Solutions for MS 023 dihydrochloride

The following data is based on the product molecular weight 360.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.78 mL	13.88 mL	27.75 mL
5 mM	0.56 mL	2.78 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.78 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for MS 023 dihydrochloride

References are publications that support the biological activity of the product.

Scheer A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 2019 PMID: 30604761
Eram A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chem.Biol. 2016 PMID: 26598975

Citations for MS 023 dihydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for MS 023 dihydrochloride include:

Tang et al. (2022) A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. Cell Rep.. 38:110417
PMID: 35196489
Lu et al. (2021) Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell. 2021;
PMID: 34171309
Choucair et al. (2019) The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer. Oncogene. 38:4015
PMID: 30692633

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