MS 4322
Tocris Bioscience, part of Bio-Techne | Catalog # 8080
Selective PRMT5 Degrader (PROTAC®)
Product Description
MS 4322 is a protein arginine methyltransferase 5 (PRMT5) Degrader (PROTAC®) (DC50 = 1.1 μM, Dmax = 74% in MCF-7 cells). Also inhibits PRMT5 methyltransferase activity (IC50 = 18 nM) and dose-dependently inhibits proliferation of HeLa, A549, A172 and Jurkat cancer cell lines. Comprises a PRMT5 inhibitor linked to an E3 ligase ligand.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
1101.33
Formula
C55H76N10O12S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide
CAS Number
2375432-47-4
PubChem ID
162652211
InChI Key
XUJMNOQMXWVXQE-STHBVIMFSA-N
SMILES
O=C(N1CC(C1)NC2=NC=NC(C(NC[C@H](O)CN3CC4=CC=CC=C4CC3)=O)=C2)COCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 110.13 | 100 |
Preparing Stock Solutions
for MS 4322
The following data is based on the product molecular weight 1101.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 5 mM | 0.18 mL | 0.91 mL | 1.82 mL |
| 10 mM | 0.09 mL | 0.45 mL | 0.91 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shen Discovery of first-in-class protein arginine methyltransferase 5 (PRMT5) degraders. J.Med.Chem. 2020 PMID: 32787082
Product Specific Notices for MS 4322
For research use only
Loading...
Loading...