(S)-PFI 2 hydrochloride

Name: ( S )-PFI 2 hydrochloride
Brand: Tocris Bioscience
SKU: 5400

Tocris Bioscience a Bio-Techne Brand

Catalog # 5400

Citations (1)

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Key Product Details

Description:	Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
Chemical Name:	8-Fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	535.98

View Full Technical Details for (S)-PFI 2 hydrochloride

Biological Activity for (S)-PFI 2 hydrochloride

(S)-PFI 2 hydrochloride is a negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC₅₀ = 1 μM) compared to the active enantiomer.

Active Analog also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (R)-PFI 2 probe summary on the SGC website.

Technical Data for (S)-PFI 2 hydrochloride

M. Wt	535.98
Formula	C₂₃H₂₅F₄N₃O₃S.HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1627607-88-8
PubChem ID	91691132
InChi Key	ZADKZNVAJGEFLC-BOXHHOBZSA-N
Smiles	O=C(N4CCCC4)[C@H](CC3=CC=CC(C(F)(F)F)=C3)NS(C2=CC1=C(C(F)=C2)CNCC1)(=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-PFI 2 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	53.6	100
	ethanol	10.72	20

Preparing Stock Solutions for (S)-PFI 2 hydrochloride

The following data is based on the product molecular weight 535.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.87 mL	9.33 mL	18.66 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.87 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for (S)-PFI 2 hydrochloride

References are publications that support the biological activity of the product.

Barsyte-Lovejoy (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc.Natl.Acad.Sci.U S A 2014 PMID: 25136132

Citations for (S)-PFI 2 hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for (S)-PFI 2 hydrochloride include:

Judson et al. (2018) Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential. Cell Stem Cell. 22:177
PMID: 29395054

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Product Documents for (S)-PFI 2 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.