WDR5 0103

Name: WDR5 0103
Brand: Tocris Bioscience
SKU: 5323
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 5323

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Key Product Details

Description:	WDR5 antagonist
Chemical Name:	3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	383.44

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Biological Activity for WDR5 0103

WDR5 0103 is a WD repeat-containing protein 5 (WDR5) antagonist (K_d = 450 nM). Disrupts WDR5 interaction with MLL and inhibits MLL core complex methyltransferase activity in vitro. Has no effect on a panel of seven other methyltransferases, including SETD7.

Compound Libraries for WDR5 0103

WDR5 0103 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for WDR5 0103

M. Wt	383.44
Formula	C₂₁H₂₅N₃O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	890190-22-4
PubChem ID	6457069
InChi Key	ZPLBXOVTSNRBFB-UHFFFAOYSA-N
Smiles	O=C(OC)C1=CC(NC(C3=CC=CC(OC)=C3)=O)=C(N2CCN(C)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WDR5 0103

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.34	100
	ethanol	19.17	50

Preparing Stock Solutions for WDR5 0103

The following data is based on the product molecular weight 383.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.04 mL	26.08 mL
5 mM	0.52 mL	2.61 mL	5.22 mL
10 mM	0.26 mL	1.30 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for WDR5 0103

References are publications that support the biological activity of the product.

Senisterra Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem.J. 2013 PMID: 22989411

Citations for WDR5 0103

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WDR5-0103 is a small-molecule antagonist of WDR5

Name: Anonymous

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: nih3t3

Reaction mixtures with various concentrations of WDR5-0103 (1 μM–1 mM) were incubated for 1 h at room temperature and then quenched by adding 20 μL of 7.5 M guanidinium chloride.

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