EPZ 015666
Tocris Bioscience, part of Bio-Techne | Catalog # 6516
Potent and selective PRMT5 inhibitor
Key Product Details
Description
Potent and selective PRMT5 inhibitor
Product Description
EPZ 015666 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 22 nM, Ki = 5 nM). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases. Exhibits dose-dependent antitumor effects in multiple mantle cell lymphoma (MCL) xenograft models. Orally bioavailable.Product Specifications
Molecular Weight
383.44
Formula
C20H25N5O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
CAS Number
1616391-65-1
PubChem ID
90241673
InChI Key
ZKXZLIFRWWKZRY-KRWDZBQOSA-N
SMILES
O[C@H](CN1CCC2=CC=CC=C2C1)CNC(C3=NC=NC(NC4COC4)=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.34 | 100 | |
| Ethanol | 19.17 | 50 |
Preparing Stock Solutions
for EPZ 015666
The following data is based on the product molecular weight 383.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chan-Penebre A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol. 2015 PMID: 25915199
- Duncan Structure and property guided design in the identification of PRMT5 tool compound EPZ015666. ACS Med.Chem.Lett. 2015 PMID: 26985292
Product Specific Notices for EPZ 015666
For research use only
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