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Apoptosis Inducer Compounds Products

Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases. These apoptosis inducers can target specific cellular processes to induce antitumor or antineoplastic effects.

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30 results for "Apoptosis Inducer Compounds" in Products

30 results for "Apoptosis Inducer Compounds" in Products

Apoptosis Inducer Compounds Products

Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases. These apoptosis inducers can target specific cellular processes to induce antitumor or antineoplastic effects.

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Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Purity: ≥98% (HPLC)
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

Antitumor antibiotic agent. Inhibits DNA topoisomerase II

Alternate Names: Adriamycin,NSC 123127
Chemical Name: 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Purity: ≥98% (HPLC)
Doxorubicin treated cardiomyocytes secrete Troponin T
(3)

DNA cross-linking antitumor agent

Alternate Names: Ametycine
Chemical Name: [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
Purity: ≥98% (HPLC)
DNA cross-linking antitumor agent

Potent pro-apoptotic anticancer agent; activates caspase-3

Alternate Names: CDDP
Chemical Name: cis-Diaminodichloroplatinum
Potent pro-apoptotic anticancer agent; activates caspase-3

Potent and selective MEK inhibitor; orally bioavailable

Chemical Name: N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
Purity: ≥98% (HPLC)
Potent and selective MEK inhibitor; orally bioavailable

Alkylating agent; chemotherapeutic

Chemical Name: 2-[bis(2-Chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
Purity: ≥98% (HPLC)
Alkylating agent; chemotherapeutic

DNA-methylating antitumor agent

Alternate Names: NSC 362856,CCRG 81045
Chemical Name: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
Purity: ≥98% (HPLC)
DNA-methylating antitumor agent

DNA cross-linking antitumor agent

Alternate Names: Eloxatin
Chemical Name: Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Purity: ≥98% (HPLC)
DNA cross-linking antitumor agent

DNA cross-linking antitumor agent

Alternate Names: NSC 241240,Paraplatin,JM 8
Chemical Name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
Purity: ≥98% (HPLC)
DNA cross-linking antitumor agent

Inhibits RNA polymerase

Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Purity: ≥95% (HPLC)
Inhibits RNA polymerase

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

Chemical Name: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
Purity: ≥98% (HPLC)
Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

Potent fatty acid synthase inhibitor; proapoptotic

Alternate Names: trans-C 75
Chemical Name: (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
Purity: ≥94% (HPLC)
Potent fatty acid synthase inhibitor; proapoptotic

Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis

Chemical Name: 6-[8-[(2-Benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-2-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis

Purine analog; inhibits DNA synthesis

Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Purity: ≥98% (HPLC)
Purine analog; inhibits DNA synthesis

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Chemical Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Purity: ≥98% (HPLC)
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

Chemical Name: (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
Purity: ≥98% (HPLC)
Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

DNA alkylator; antitumor and induces diabetes

Alternate Names: Streptozotocin
Chemical Name: 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
Purity: ≥95% (HPLC)
DNA alkylator; antitumor and induces diabetes

Hypoxia-activated DNA alkylating agent prodrug

Chemical Name: (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
Applications: AdAct
Purity: ≥98% (HPLC)
Hypoxia-activated DNA alkylating agent prodrug

Suppressor of MDK expression; inhibits PI 3-K signaling

Chemical Name: 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)
Suppressor of MDK expression; inhibits PI 3-K signaling

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

Alternate Names: Kempferol
Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist

Chemical Name: (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Chemical Name: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
Purity: ≥98% (HPLC)
High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Potent and selective HDAC8 inhibitor

Chemical Name: N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
Purity: ≥98% (HPLC)
Potent and selective HDAC8 inhibitor

High affinity and selective activator of Bax

Chemical Name: 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
Purity: ≥98% (HPLC)
High affinity and selective activator of Bax

Potent UNC-51-like kinase 1 (ULK1) agonist

Chemical Name: 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride
Purity: ≥98% (HPLC)
Potent UNC-51-like kinase 1 (ULK1) agonist
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