ABT 263

Tocris Bioscience, part of Bio-Techne | Catalog # 7680

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
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Key Product Details

Description

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

View all Bcl-2 Family Inhibitors »

Product Description

ABT 263 is a high affinity inhibitor of Bcl-2 family proteins (Ki values are 0.5 nM, <1 nM and <1 nM in Bcl-xL, Bcl-2 and Bcl-W respectively). ABT 263 induces G1/G0 phase arrest, apoptosis and autophagy in cancer cells in vitro (IC50 = 3.4 - 12 μM). In vivo, ABT 263 displays a synergistic antitumor effect with rituximab and Bortezomib (Cat. No. 7282), Docetaxel (Cat. No. 4056) and Erlotinib (Cat. No. 7194), and inhibits growth of SCLC xenografts when combined with (+)-JQ1 (Cat. No. 4499). ABT 263 also reduces inflammation and viral-induced senescence in SARS-CoV-2 infection in vivo, and clears senescent cells and rejuvenates aging stem cells. Orally bioavailable.

Product Specifications

Molecular Weight

974.62

Formula

C47H55ClF3N5O6S3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide

CAS Number

923564-51-6

PubChem ID

24978538

InChI Key

JLYAXFNOILIKPP-KXQOOQHDSA-N

SMILES

C(C1=C(CCC(C)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C=C5)=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 97.46 100

Preparing Stock Solutions for ABT 263

The following data is based on the product molecular weight 974.62

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.13 mL 10.26 mL
5 mM 0.21 mL 1.03 mL 2.05 mL
10 mM 0.10 mL 0.51 mL 1.03 mL
50 mM 0.02 mL 0.10 mL 0.21 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for ABT 263

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ABT 263

For research use only

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