Key Product Details
Description: | Potent and selective BET bromodomain inhibitor; cell permeable |
Chemical Name: | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 456.99 |
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Citations for (+)-JQ1 (12)
Citations are publications that use Bio-Techne products. Selected citations for (+)-JQ1 include:
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Noblejas-Lopez et al.
(2019)
Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer.
J Exp Clin Cancer Res.
38:383
PMID: 31470872 -
Andrieu et al.
(2019)
BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response.
Cancer Lett.
465:45
PMID: 31473251 -
Lin et al.
(2019)
Super-Enhancer-Associated LncRNA UCA1 Interacts Directly with AMOT to Activate YAP Target Genes in Epithelial Ovarian Cancer.
iScience.
17:242
PMID: 31307004 -
Sakaguchi
(2018)
Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma.
Oncotarget.
9(33):23003
PMID: 29796168 -
Georgilis et al.
(2018)
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
Cancer Cell.
34:85
PMID: 29990503 -
Xie et al.
(2018)
IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.
J Clin Invest.
128:1300
PMID: 29381485 -
Chen
(2017)
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis.
Nat Commun.
8(1):383
PMID: 28851877 -
Jang et al.
(2017)
AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells.
Clin Cancer Res.
23:2781
PMID: 27864418 -
Kato et al.
(2016)
MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.
Oncotarget.
7:77378
PMID: 27764802 -
Shao et al.
(2016)
Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains.
Cell Rep.
16:3138
PMID: 27653680 -
Perry et al.
(2015)
BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle.
Nat Commun.
290:9111
PMID: 25697361 -
Sartor et al.
(2015)
Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity.
J Neurosci.
35:15062
PMID: 26558777
There are no citations that match your criteria.
Customer Reviews for (+)-JQ1 (2)
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Species: HumanAssay Type: In VitroCell Line/Tissue: U2OSJQ1 (1 μM)
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Species: MouseAssay Type: In VitroCell Line/Tissue: ipsc500 nM
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