(+)-JQ1 carboxylic acid

Name: (+)-JQ1 carboxylic acid
Brand: Tocris Bioscience
SKU: 6588
Price: 525 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 6588

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Key Product Details

Description:	Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs
Chemical Name:	(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	400.88

View Full Technical Details for (+)-JQ1 carboxylic acid

Biological Activity for (+)-JQ1 carboxylic acid

(+)-JQ1 carboxylic acid is a BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499) with a carboxylic acid functional group for conjugation reactions. Can be used as a precursor to PROTAC^® Degraders that targets BET bromodomains after conjugation to a linker and E3 ligase ligand.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for (+)-JQ1 carboxylic acid

M. Wt	400.88
Formula	C₁₉H₁₇ClN₄O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	202592-23-2
PubChem ID	66828107
InChi Key	LJOSBOOJFIRCSO-AWEZNQCLSA-N
Smiles	OC(C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=C(SC(C)=C3C)N4C1=NN=C4C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-JQ1 carboxylic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.09	100
	ethanol	40.09	100

Preparing Stock Solutions for (+)-JQ1 carboxylic acid

The following data is based on the product molecular weight 400.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.47 mL	24.95 mL
5 mM	0.50 mL	2.49 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for (+)-JQ1 carboxylic acid

References are publications that support the biological activity of the product.

Gadd Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat.Chem.Biol. 2017 PMID: 28288108
Winter DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 2015 PMID: 25999370
Zengerle Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem Biol. 2015 PMID: 26035625

Citations for (+)-JQ1 carboxylic acid

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