157 results for "Degrader Building Blocks" in Products
Degrader Building Blocks Products
Functionalized VHL building block for copper-free click chemistry
| Chemical Name: | ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate |
| Purity: | ≥90% (HPLC) |
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
| Chemical Name: | 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid |
| Purity: | ≥90% (HPLC) |
Biotinylated ASGPR ligand for LYTAC research and development
| Purity: | ≥90% (HPLC) |
Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
| Chemical Name: | N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide |
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control
| Chemical Name: | 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Amine functionalized VHL ligand for PROTAC® research
| Chemical Name: | (4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG2-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | 4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal acid for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG5-COOH |
| Chemical Name: | (S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid |
| Purity: | ≥95% (HPLC) |
Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
| Chemical Name: | 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside |
| Purity: | ≥95% (HPLC) |
Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
| Purity: | ≥90% (HPLC) |
Cereblon ligand with terminal piperazine for onward chemistry
| Chemical Name: | 3-[1,3-Dihydro-1-oxo-5-(1-piperazinyl)-2H-isoindol-2-yl]-2,6-piperidinedione hydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride |
| Purity: | ≥94% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | Thalidomide - linker 10 |
| Chemical Name: | N-(2-Aminoethyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | 4-[(8-Aminooctyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | VH 032 - linker 8,(S,R,S)-AHPC-C2-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(7-Aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(17-Azido-3,6,9,12,15-pentaoxaheptadecyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 2-(2,6-Dioxo-3-piperidinyl)-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-1H-isoindole-1,3(2H)-dione dihydrochloride |
| Purity: | ≥95% (HPLC) |
Functionalized cereblon ligand for PROTAC development
| Chemical Name: | 4-Methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoic acid |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-6-[4-(4-piperidinylmethyl)-1-piperazinyl]-1H-isoindole-1,3(2H)-dione dihydrochloride |
| Purity: | ≥95% (HPLC) |
Functionalized cereblon ligand for PROTAC development
| Chemical Name: | 2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(5-Azidopentyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name: | 4-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name: | 4-[(6-Azidohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | 3-[4-[[2-(2-Aminoethoxy)ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride |
| Purity: | ≥95% (HPLC) |
