A 410099.1, amine

Name: A 410099.1, amine
Brand: Tocris Bioscience
SKU: 6471

Tocris Bioscience, part of Bio-Techne | Catalog # 6471

Citations (16)

COA / SDS

Functionalized IAP ligand for PROTACs

Key Product Details

Description:	Functionalized IAP ligand for PROTACs
Chemical Name:	tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	620.22

View Full Technical Details for A 410099.1, amine

Technical Data
Citations

Biological Activity for A 410099.1, amine

A 410099.1, amine is a functionalized IAP ligand for PROTAC^® research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC₅₀ values of 4.6, 9.2 and 15.6 nM for cIAP1, cIAP2 and XIAP proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for A 410099.1, amine

M. Wt	620.22
Formula	C₃₂H₄₉N₅O₅.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2374122-37-7
InChi Key	XWVNETXEAKCZET-CZNZTGDVSA-N
Smiles	C[C@@H](C(N[C@H](C(N1C[C@H](C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)N)=O)C4CCCCC4)=O)N(C(OC(C)(C)C)=O)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for A 410099.1, amine

References are publications that support the biological activity of the product.

Schwalm A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins. Front.Cell.Dev.Biol. 2022 PMID: 35721509
Tinworth PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Chem.Biol. 2019 PMID: 30807093