A 410099.1, amine

Tocris Bioscience, part of Bio-Techne | Catalog # 6471

Functionalized IAP ligand for PROTACs
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Key Product Details

Description

Functionalized IAP ligand for PROTACs

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Product Description

A 410099.1, amine is a functionalized IAP ligand for PROTAC® research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC50 values of 4.6, 9.2 and 15.6 nM for cIAP1, cIAP2 and XIAP proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

620.22

Formula

C32H49N5O5.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride

CAS Number

2374122-37-7

InChI Key

XWVNETXEAKCZET-CZNZTGDVSA-N

SMILES

C[C@@H](C(N[C@H](C(N1C[C@H](C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)N)=O)C4CCCCC4)=O)N(C(OC(C)(C)C)=O)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for A 410099.1, amine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 410099.1, amine

For research use only

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