tri-GalNAc COOH
Tocris Bioscience, part of Bio-Techne | Catalog # 7401
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
Key Product Details
Description
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
Product Description
Tri-GalNAc COOH is a functionalized asialoglycoprotein receptor ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates an asialoglycoprotein receptor (ASGPR) ligand with PEG linker and carboxylic acid group reactive handle ready for conjugation to a target protein ligand. Upon binding to the ASGPR tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. Tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes.Product Specifications
Molecular Weight
1735.93
Formula
C75H134N10O35
Storage
Store at -20°C
Purity
≥90% (HPLC)
Chemical Name
36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
CAS Number
1953146-81-0
InChI Key
SPYOMGAJOYWUJU-JNYSMVCCSA-N
SMILES
O=C(CCOCCOCCOCCOCCOCCC(O)=O)NC(COCCC(NCCCNC(CCCCOC1O[C@@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCOC2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)COCCC(NCCCNC(CCCCOC3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 86.8 | 50 |
Preparing Stock Solutions
for tri-GalNAc COOH
The following data is based on the product molecular weight 1735.93
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.15 mL | 5.76 mL | 11.52 mL |
| 2.5 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 5 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 25 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhou Development of triantennary N-Acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent. Sci. 2021 PMID: 33791431
Product Specific Notices for tri-GalNAc COOH
For research use only
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