tri-GalNAc COOH

Name: tri-GalNAc COOH
Brand: Tocris Bioscience
SKU: 7401
Price: 353 USD

Catalog # 7401 | Tocris Bioscience a Bio-Techne Brand

COA / SDS

Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

Key Product Details

Description:	Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
Chemical Name:	36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
Purity:	≥90% (HPLC)
Molecular Weight:	1735.93

View Full Technical Details for tri-GalNAc COOH

Biological Activity for tri-GalNAc COOH

Tri-GalNAc COOH is a functionalized asialoglycoprotein receptor ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates an asialoglycoprotein receptor (ASGPR) ligand with PEG linker and carboxylic acid group reactive handle ready for conjugation to a target protein ligand. Upon binding to the ASGPR tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. Tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes.

Technical Data for tri-GalNAc COOH

M. Wt	1735.93
Formula	C₇₅H₁₃₄N₁₀O₃₅
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	1953146-81-0
InChi Key	SPYOMGAJOYWUJU-JNYSMVCCSA-N
Smiles	O=C(CCOCCOCCOCCOCCOCCC(O)=O)NC(COCCC(NCCCNC(CCCCOC1O[C@@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCOC2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)COCCC(NCCCNC(CCCCOC3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for tri-GalNAc COOH

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	86.8	50

Preparing Stock Solutions for tri-GalNAc COOH

The following data is based on the product molecular weight 1735.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.15 mL	5.76 mL	11.52 mL
2.5 mM	0.23 mL	1.15 mL	2.30 mL
5 mM	0.12 mL	0.58 mL	1.15 mL
25 mM	0.02 mL	0.12 mL	0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for tri-GalNAc COOH

References are publications that support the biological activity of the product.

Zhou Development of triantennary N-Acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent. Sci. 2021 PMID: 33791431

Citations for tri-GalNAc COOH

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.