tri-GalNAc biotin
Tocris Bioscience, part of Bio-Techne | Catalog # 7635
Biotinylated ASGPR ligand for LYTAC research and development
Key Product Details
Description
Biotinylated ASGPR ligand for LYTAC research and development
Product Description
Tri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).Product Specifications
Molecular Weight
1916.21
Formula
C83H146N14O34S
Storage
Store at -20°C
Purity
≥90% (HPLC)
CAS Number
3062597-46-7
InChI Key
GFCCTIAQGWLOHY-PTYDYDFOSA-N
SMILES
O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OCCCCC(NCCCNC(CCOCC(NC(CCNC(CCOCCOCCOCCNC(CCCC[C@@H]2SC[C@@](N3)([H])[C@]2([H])NC3=O)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@@H]5O[C@H](CO)[C@H](O)[C@H](O)[C@H]5NC(C)=O)=O)=O)=O)=O)O[C@@H]1CO
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 95.81 | 50 |
Preparing Stock Solutions
for tri-GalNAc biotin
The following data is based on the product molecular weight 1916.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.04 mL | 5.22 mL | 10.44 mL |
| 2.5 mM | 0.21 mL | 1.04 mL | 2.09 mL |
| 5 mM | 0.10 mL | 0.52 mL | 1.04 mL |
| 25 mM | 0.02 mL | 0.10 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhou Development of triantennary N-acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent.Sci. 2021 PMID: 33791431
Product Specific Notices for tri-GalNAc biotin
For research use only
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