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Degrader Building Blocks: Small Molecules and Peptides
148 results for "Degrader Building Blocks Small Molecules and Peptides" in Products
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Degrader Building Blocks: Small Molecules and Peptides
148 results for "Degrader Building Blocks Small Molecules and Peptides" in Products
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
| Chemical Name : | 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid |
| Purity : | ≥90% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name : | 3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride |
| Purity : | ≥95% (HPLC) |
Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs
| Chemical Name : | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-N-2-propyn-1-yl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity : | ≥95% (HPLC) |
Functionalized cereblon ligand for PROTAC development
| Chemical Name : | 2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid |
| Purity : | ≥95% (HPLC) |
Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
| Chemical Name : | N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide |
| Purity : | ≥90% (HPLC) |
VHL ligand with alkyl linker and terminal acid for onward chemistry
| Alternate Names : | (S,R,S)-AHPC-C8-COOH |
| Chemical Name : | 10-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-10-oxodecanoic acid |
| Purity : | ≥95% (HPLC) |
Functionalized VHL ligand for PROTACs
| Chemical Name : | (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride |
| Purity : | ≥98% (HPLC) |
Functionalized cereblon ligand for PROTAC development
| Chemical Name : | 4-Methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoic acid |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names : | Thalidomide - linker 11 |
| Chemical Name : | 4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity : | ≥95% (HPLC) |
Functionalized IAP ligand for PROTACs
| Chemical Name : | tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride |
| Purity : | ≥98% (HPLC) |
Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs
| Chemical Name : | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid |
| Purity : | ≥98% (HPLC) |
Precursor to Pomalidomide-based PROTACs
| Chemical Name : | 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione |
| Purity : | ≥98% (HPLC) |
Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
| Chemical Name : | 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione |
| Purity : | ≥95% |
VHL ligand with alkyl linker and terminal acid for onward chemistry
| Alternate Names : | (S,R,S)-AHPC-C4-COOH |
| Chemical Name : | 6-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names : | Thalidomide - linker 9 |
| Chemical Name : | 4-(4-Aminobutoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names : | Thalidomide - linker 14 |
| Chemical Name : | N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name : | 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name : | 4-[[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal alkyne for onward chemistry
| Alternate Names : | Thalidomide - linker 5 |
| Chemical Name : | 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name : | 4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name : | 4-[(6-Azidohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity : | ≥95% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Alternate Names : | Thalidomide - linker 13 |
| Chemical Name : | N-[2-(2-Aminoethoxy)ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide |
| Purity : | ≥95% (HPLC) |
Hydroxyl functionalized VHL ligand
| Alternate Names : | (S,R,S)-AHPC-phenol |
| Chemical Name : | (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity : | ≥98% (HPLC) |
Hydroxyl functionalized VHL ligand
| Chemical Name : | (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity : | ≥98% (HPLC) |
