(-)-JQ1
Tocris Bioscience, part of Bio-Techne | Catalog # 5603
Negative control for (+)-JQ1
Product Description
(-)-JQ1 is an inactive control for (+)-JQ1. Exhibits no significant interaction with BRD1-4 or a panel of other bromodomains.Active Enantiomer also available.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (+)-JQ1 probe summary on the SGC website.Product Specifications
Molecular Weight
456.99
Formula
C23H25ClN4O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(6R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
CAS Number
1268524-71-5
PubChem ID
49871818
InChI Key
DNVXATUJJDPFDM-QGZVFWFLSA-N
SMILES
O=C(OC(C)(C)C)C[C@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.7 | 100 | |
| Ethanol | 45.7 | 100 |
Preparing Stock Solutions
for (-)-JQ1
The following data is based on the product molecular weight 456.99
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.94 mL | 21.88 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Filippakopoulos Selective inhibition of BET bromodomains. Nature 2010 PMID: 20871596
Product Specific Notices for (-)-JQ1
For research use only
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