(-)-JQ1

Name: (-)-JQ1
Brand: Tocris Bioscience
SKU: 5603
Price: 381 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 5603

Citations (2)

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Key Product Details

Description:	Negative control for (+)-JQ1
Chemical Name:	(6R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	456.99

View Full Technical Details for (-)-JQ1

Biological Activity for (-)-JQ1

(-)-JQ1 is an inactive control for (+)-JQ1. Exhibits no significant interaction with BRD1-4 or a panel of other bromodomains.

Active Enantiomer also available.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (+)-JQ1 probe summary on the SGC website.

Compound Libraries for (-)-JQ1

(-)-JQ1 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for (-)-JQ1

M. Wt	456.99
Formula	C₂₃H₂₅ClN₄O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1268524-71-5
PubChem ID	49871818
InChi Key	DNVXATUJJDPFDM-QGZVFWFLSA-N
Smiles	O=C(OC(C)(C)C)C[C@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (-)-JQ1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.7	100
	ethanol	45.7	100

Preparing Stock Solutions for (-)-JQ1

The following data is based on the product molecular weight 456.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.94 mL	21.88 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.09 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for (-)-JQ1

References are publications that support the biological activity of the product.

Filippakopoulos Selective inhibition of BET bromodomains. Nature 2010 PMID: 20871596

Citations for (-)-JQ1 (2)

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Citations are publications that use Bio-Techne products. Selected citations for (-)-JQ1 include:

Andrieu et al. (2019) BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response. Cancer Lett. 465:45
PMID: 31473251
Perry et al. (2015) BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle. Scientific Reports. 290:9111
PMID: 25697361

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