(+)-JQ1 PA

Tocris Bioscience, part of Bio-Techne | Catalog # 6589

Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs
Discontinued Product
6589 has been discontinued. View all Degrader Building Blocks products.

Key Product Details

Description

Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs

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Product Description

(+)-JQ1 PA is a click-activated (alkyne) version of the BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499). Can be used as a precursor to a PROTAC® targeting BET bromodomains. Supplied with an alkyne functionalized handle for click conjugation to a linker/E3 ligase ligand. Can also be conjugated to fluorescent dyes for imaging aplications.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications

Molecular Weight

437.95

Formula

C22H20ClN5OS

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-N-2-propyn-1-yl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

CAS Number

2115701-93-2

PubChem ID

134821687

InChI Key

ZLSCJWMPQYKVKU-KRWDZBQOSA-N

SMILES

O=C(NCC#C)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=C(SC(C)=C3C)N4C1=NN=C4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.8 100
Ethanol 43.8 100

Preparing Stock Solutions for (+)-JQ1 PA

The following data is based on the product molecular weight 437.95

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for (+)-JQ1 PA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (+)-JQ1 PA

For research use only

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