(+)-JQ1 PA

Name: (+)-JQ1 PA
Brand: Tocris Bioscience
SKU: 6589
Price: 528 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 6589

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Key Product Details

Description:	Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs
Chemical Name:	(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-N-2-propyn-1-yl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:	≥95% (HPLC)
Molecular Weight:	437.95

View Full Technical Details for (+)-JQ1 PA

Biological Activity for (+)-JQ1 PA

(+)-JQ1 PA is a click-activated (alkyne) version of the BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499). Can be used as a precursor to a PROTAC^® targeting BET bromodomains. Supplied with an alkyne functionalized handle for click conjugation to a linker/E3 ligase ligand. Can also be conjugated to fluorescent dyes for imaging aplications.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for (+)-JQ1 PA

M. Wt	437.95
Formula	C₂₂H₂₀ClN₅OS
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2115701-93-2
PubChem ID	134821687
InChi Key	ZLSCJWMPQYKVKU-KRWDZBQOSA-N
Smiles	O=C(NCC#C)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=C(SC(C)=C3C)N4C1=NN=C4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-JQ1 PA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.8	100
	ethanol	43.8	100

Preparing Stock Solutions for (+)-JQ1 PA

The following data is based on the product molecular weight 437.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.42 mL	22.83 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for (+)-JQ1 PA

References are publications that support the biological activity of the product.

Tyler Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science 2017 PMID: 28619718

Citations for (+)-JQ1 PA

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