Docetaxel

Name: Docetaxel
Brand: Tocris Bioscience
SKU: 4056
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4056

Citations (4)

(1)

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Key Product Details

Description:	Microtubule stabilizer
Chemical Name:	[2aR-[2aα,4β,4aβ,6β,9α(αR,βS),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	807.88

View Full Technical Details for Docetaxel

Biological Activity for Docetaxel

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

Compound Libraries for Docetaxel

Docetaxel is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Docetaxel

M. Wt	807.88
Formula	C₄₃H₅₃NO₁₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	114977-28-5
PubChem ID	148124
InChi Key	ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Smiles	O[C@@H]1C4=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C[C@@](C(C)4C)(O)[C@@H](OC(C6=CC=CC=C6)=O)[C@@]([C@@]3(OC(C)=O)[C@H](OC3)C[C@@H]2O)([H])[C@]2(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Docetaxel

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	80.79	100
	ethanol	80.79	100

Preparing Stock Solutions for Docetaxel

The following data is based on the product molecular weight 807.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.24 mL	6.19 mL	12.38 mL
5 mM	0.25 mL	1.24 mL	2.48 mL
10 mM	0.12 mL	0.62 mL	1.24 mL
50 mM	0.02 mL	0.12 mL	0.25 mL

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References for Docetaxel

References are publications that support the biological activity of the product.

Ramaswamy and Puhalla Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors. Drugs Today (Barc) 2006 PMID: 16703123
Lyseng-Williamson and Fenton Docetaxel: a review of its use in metastatic breast cancer. Drugs 2005 PMID: 16296875

Citations for Docetaxel (4)

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Citations are publications that use Bio-Techne products. Selected citations for Docetaxel include:

Mabe et al. (2018) Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. J Clin Invest. 128:4413
PMID: 30148456
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther. 16(6):1021
PMID: 28265007
Kathawala et al. (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget. 6:510
PMID: 25402202
Kathawala et al. (2014) Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study. Mol Cancer Ther. 13:714
PMID: 24431074

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Customer Reviews for Docetaxel (1)

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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007

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