alpha-1A Adrenergic R/ADRA1A: Small Molecules and Peptides
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G proteins. These various subtypes show different patterns of activation. ADRA1A encodes the alpha-1A-adrenergic receptor. ADRA1A is expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary.
18 results for "alpha-1A Adrenergic R/ADRA1A Small Molecules and Peptides" in Products
18 results for "alpha-1A Adrenergic R/ADRA1A Small Molecules and Peptides" in Products
alpha-1A Adrenergic R/ADRA1A: Small Molecules and Peptides
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G proteins. These various subtypes show different patterns of activation. ADRA1A encodes the alpha-1A-adrenergic receptor. ADRA1A is expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary.
α1 agonist
| Chemical Name: | (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride |
| Purity: | ≥98% (HPLC) |
α1 and α2B antagonist; also MT3 antagonist
| Chemical Name: | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride |
| Purity: | ≥98% (HPLC) |
α1, β1 and β2 agonist
| Chemical Name: | 4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]aminoethyl-1,2-benzenediol hydrochloride |
| Purity: | ≥98% (HPLC) |
Psychostimulant
| Alternate Names: | CRL 40476 |
| Chemical Name: | 2-[(Diphenylmethyl)sulfinyl]acetamide |
| Purity: | ≥98% (HPLC) |
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
| Chemical Name: | (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate |
| Purity: | ≥98% (HPLC) |
α1 antagonist; PGK1 activator
| Chemical Name: | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride |
| Purity: | ≥98% (HPLC) |
α1 antagonist
| Alternate Names: | UK 33274 |
| Chemical Name: | 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate |
| Purity: | ≥98% (HPLC) |
Selective α1 agonist
| Chemical Name: | 2-(2-Cyclopropylphenoxymethyl)imidazoline hydrochloride |
| Purity: | ≥98% (HPLC) |
α1A agonist
| Chemical Name: | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide |
Selective α1A adrenergic receptor Degrader (PROTAC®)
| Chemical Name: | 2-(2-(2-(2-(4-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide |
| Purity: | ≥98% (HPLC) |
Potent and selective adrenergic α2B antagonist
| Chemical Name: | 1-[2-[[[3-(3,5-Dimethyl-4-isoxazolyl)imidazo[1,2-a]pyridin-7-yl]carbonyl]amino]ethyl]-4-(methylamino)pyridinium chloride |
| Purity: | ≥98% (HPLC) |
CCR2b chemokine receptor antagonist
| Chemical Name: | 1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and non-selective β antagonist; also potent α1 antagonist
| Alternate Names: | BM 14190 |
| Chemical Name: | 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol |
| Purity: | ≥98% (HPLC) |
Highly selective α1 antagonist
| Alternate Names: | BE 2254 |
| Chemical Name: | 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent, subtype-selective α1A antagonist
| Chemical Name: | 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
| Alternate Names: | Org 3770,6-Azamianserin |
| Chemical Name: | 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine |
| Purity: | ≥98% (HPLC) |
Selective α1A antagonist
| Chemical Name: | 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective α1A antagonist
| Chemical Name: | 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide |
| Purity: | ≥98% (HPLC) |
