Silodosin

Name: Silodosin
Brand: Tocris Bioscience
SKU: 6663

Tocris Bioscience a Bio-Techne Brand

Catalog # 6663

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Key Product Details

Description:	Selective α_1A antagonist
Chemical Name:	2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	495.53

View Full Technical Details for Silodosin

Biological Activity for Silodosin

Silodosin is a selective α_1A adrenoceptor antagonist (K_i = 0.036 nM). Displays >55 fold selectivity for α_1A over α_1B and α_1D. Inhibits norepinephrine-induced [Ca²⁺]_I increase in α_1A expressing CHO cells (IC₅₀ = 0.32 nM). Inhibits norepinephrine-induced contraction of isolated human prostate tissue.

Compound Libraries for Silodosin

Silodosin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Silodosin

M. Wt	495.53
Formula	C₂₅H₃₂F₃N₃O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	160970-54-7
PubChem ID	5312125
InChi Key	PNCPYILNMDWPEY-QGZVFWFLSA-N
Smiles	C[C@@H](NCCOC1=C(C=CC=C1)OCC(F)(F)F)CC2=CC(C(N)=O)=C3N(CCC3=C2)CCCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Silodosin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	49.55	100
	ethanol	49.55	100

Preparing Stock Solutions for Silodosin

The following data is based on the product molecular weight 495.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.09 mL	20.18 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for Silodosin

References are publications that support the biological activity of the product.

Moriyama KMD-3213, a novel alpha1A-adrenoceptor antagonist, potently inhibits the functional alpha1-adrenoceptor in human prostate. Eur.J.Pharmacol. 1997 PMID: 9274928
Shibata KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol.Pharmacol. 1995 PMID: 7651358

Citations for Silodosin

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