Mirtazapine

Product Description

Mirtazapine is an antidepressant agent; potent 5-HT₂, 5-HT₃ and histamine H₁ receptor antagonist and moderately potent α₂-adrenoceptor antagonist (pK_i values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenaline (NA) release in rat brain via inhibition of α₂-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pK_i values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.

Solubility

Preparing Stock Solutions for Mirtazapine

The following data is based on the product molecular weight 265.36

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.54 mL	37.68 mL	75.37 mL
2.5 mM	1.51 mL	7.54 mL	15.07 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
25 mM	0.15 mL	0.75 mL	1.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kooyman Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. Neuropharmacology 1994 PMID: 7984289
• de Boer Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazepine, mianserin and idazoxan. J.Pharmacol.Exp.Ther. 1996 PMID: 8627567
• de Boer Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, ORG 3770 and its enantiomers. Neuropharmacology 1988 PMID: 3419539