(R)-(-)-Phenylephrine hydrochloride

Name: ( R )-(-)-Phenylephrine hydrochloride
Brand: Tocris Bioscience
SKU: 2838
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2838

(1)

Citations (40)

COA / SDS

α1 agonist

Key Product Details

Description:	α₁ agonist
Chemical Name:	(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	203.67

View Full Technical Details for (R)-(-)-Phenylephrine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for (R)-(-)-Phenylephrine hydrochloride

(R)-(-)-Phenylephrine hydrochloride is a α₁-adrenoceptor agonist; pK_i values are 5.86, 4.87 and 4.70 for α_1D, α_1B and α_1A receptors respectively.

Compound Libraries for (R)-(-)-Phenylephrine hydrochloride

(R)-(-)-Phenylephrine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Scientific Data Examples for (R)-(-)-Phenylephrine hydrochloride

	Small molecules affect cardiomyocyte contraction rates. The effect of small molecules on cardiomyocyte contraction rate was assessed by monitoring intracellular calcium fluctuations, where an increase in calcium coincides with cardiomyocyte contraction. Cardiomyocytes were loaded with the fluorescent calcium indicator, Fluo-4, prior to small molecule treatment. Individual wells were first monitored for baseline rates of calcium fluctuation represented as beats per minute (bpm). Phenylephrine (3μM, Catalog # 2838), an alpha 1-adrenoceptor agonist, increased the calcium fluctuation rate of cardiomyocytes compared to untreated cells

Technical Data for (R)-(-)-Phenylephrine hydrochloride

M. Wt	203.67
Formula	C₉H₁₃NO₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	61-76-7
PubChem ID	441279
InChi Key	OCYSGIYOVXAGKQ-FVGYRXGTSA-N
Smiles	OC1=CC=CC([C@@H](O)CNC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(-)-Phenylephrine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.37	100
	DMSO	20.37	100

Preparing Stock Solutions for (R)-(-)-Phenylephrine hydrochloride

The following data is based on the product molecular weight 203.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.91 mL	24.55 mL	49.10 mL
5 mM	0.98 mL	4.91 mL	9.82 mL
10 mM	0.49 mL	2.45 mL	4.91 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (R)-(-)-Phenylephrine hydrochloride

References are publications that support the biological activity of the product.

Ford Pharmacological pleiotropism of the human recombinant α_1A-adrenoceptor: implications for α₁-adrenoceptor classification. Br.J.Pharmacol. 1997 PMID: 9249248
Morton α_1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 2007 PMID: 17115072
Minneman Selectivity of agonists for cloned α₁-adrenergic receptor subtypes. Mol.Pharmacol. 1994 PMID: 7969082