Modafinil
Tocris Bioscience, part of Bio-Techne | Catalog # 1811
Psychostimulant
Key Product Details
Description
Psychostimulant
Alternative Names
CRL 40476
Product Description
Modafinil is a psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Modafinil promotes vigilance and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.Product Specifications
Molecular Weight
273.35
Formula
C15H15NO2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[(Diphenylmethyl)sulfinyl]acetamide
CAS Number
68693-11-8
PubChem ID
4236
InChI Key
YFGHCGITMMYXAQ-UHFFFAOYSA-N
SMILES
O=S(CC(N)=O)C(C2=CC=CC=C2)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.5 | 75 | |
| Ethanol | 2.73 | 10 |
Preparing Stock Solutions
for Modafinil
The following data is based on the product molecular weight 273.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 4.88 mL | 24.39 mL | 48.78 mL |
| 3.75 mM | 0.98 mL | 4.88 mL | 9.76 mL |
| 7.5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
| 37.5 mM | 0.10 mL | 0.49 mL | 0.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jenner Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset. Exp.Brain Res. 2000 PMID: 10968218
- Madras Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 2006 PMID: 16885432
- Ferraro Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers. Biol.Psychiatry 1997 PMID: 9426889
Product Specific Notices for Modafinil
For research use only
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