RS 102895 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2089
CCR2b chemokine receptor antagonist
Key Product Details
Description
CCR2b chemokine receptor antagonist
Product Description
RS 102895 hydrochloride is a CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Also inhibits α1A, α1D and 5-HT1A receptors.Product Specifications
Molecular Weight
426.86
Formula
C21H21F3N2O2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride
CAS Number
1173022-16-6
PubChem ID
16759153
InChI Key
KRRISOFSWVKYBF-UHFFFAOYSA-N
SMILES
Cl.FC(F)(F)C1=CC=C(CCN2CCC3(CC2)OC(=O)NC2=CC=CC=C32)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.01 | 75 |
Preparing Stock Solutions
for RS 102895 hydrochloride
The following data is based on the product molecular weight 426.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 3.12 mL | 15.62 mL | 31.24 mL |
| 3.75 mM | 0.62 mL | 3.12 mL | 6.25 mL |
| 7.5 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 37.5 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mirzadegan Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 2000 PMID: 10770925
- Clark Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones. J.Med.Chem. 1983 PMID: 6842505
Product Specific Notices for RS 102895 hydrochloride
For research use only
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