A 61603 hydrobromide

Name: A 61603 hydrobromide
Brand: Tocris Bioscience
SKU: 1052
Rating: 5 (1 reviews)

Catalog # 1052

Citations (12)

(1)

COA / SDS

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Key Product Details

Description:	α_1A agonist
Chemical Name:	N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
Molecular Weight:	390.29

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Biological Activity

A 61603 hydrobromide is a potent α-adrenoceptor agonist that is at least 35-fold more potent at α_1A than at α_1B or α_1D sites. Induces dose response increases in spontaneous Ca²⁺ transients in rat ventricular myocytes in vitro (EC₅₀ = 6.9 nmol/L).

Technical Data

M. Wt	390.29
Formula	C₁₄H₁₉N₃O₃S.HBr
Storage	Desiccate at +4°C
CAS Number	107756-30-9
PubChem ID	9865178
InChi Key	LRFLWCZMTGTUEP-UHFFFAOYSA-N
Smiles	Br.CS(=O)(=O)NC1=C(O)C=CC2=C1CCCC2C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		50

Preparing Stock Solutions

The following data is based on the product molecular weight 390.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.12 mL	25.62 mL	51.24 mL
2.5 mM	1.02 mL	5.12 mL	10.25 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

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References

References are publications that support the biological activity of the product.

Luo Receptor subtype involved in α_1A-adrenergic receptor-mediated Ca²⁺ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 2007 PMID: 17588332
Meyer Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α_1A receptor agonist. J.Med.Chem. 1996 PMID: 8831777
Knepper A-61603, a potent α₁-adrenergic receptor agonist, selective for the α_1A receptor subtype. J.Pharmacol.Exp.Ther. 1995 PMID: 7616455

Citations for A 61603 hydrobromide (12)

Showing 1 - 10 of 12 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for A 61603 hydrobromide include:

Montgomery (2017) An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice. Plos One. 12:e0168409
PMID: 28081170
Thomas et al. (2016) The α-1A Adrenergic Receptor in the Rabbit Heart. Nephrol Dial Transplant. 11:e0155238
PMID: 27258143
Treen et al. (2016) Divergent regulation of ER and kiss genes by 17�-OE in hypothalamic ARC versus AVPV models. Mol.Endocrinol.. 30:217
PMID: 26726951
Thomas et al. (2016) A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci. 1:155
PMID: 27453955
Copik et al. (2015) Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. PLoS One. 10:e0115701
PMID: 25606852
Desir and Peixoto (2014) Renalase in hypertension and kidney disease. Circ Res. 29:42604
PMID: 24137013
Amirak et al. (2013) p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. Biochem J. 450:351
PMID: 23215897
Dash et al. (2011) A molecular MRI probe to detect treatment of cardiac apoptosis in vivo. Magn Reson Med. 66:1152
PMID: 21360750
Jensen et al. (2010) Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 382:475
PMID: 20857090
Jensen et al. (2009) The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries. PLoS One. 54:1137
PMID: 19761933
O-Uchi et al. (2008) Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. PLoS One. 102:1378
PMID: 18467629
Rokosh and Simpson (2002) Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc Natl Acad Sci U S A. 99:9474
PMID: 12093905

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A61603 works well on H9C2

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: H9C2

A61603 was used to treat H9C2 for 24hours, works well as intended.

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