Tamsulosin hydrochloride

Name: Tamsulosin hydrochloride
Brand: Tocris Bioscience
SKU: 3050
Rating: 5 (1 reviews)

Catalog # 3050 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (3)

COA / SDS

Selective α1A antagonist

Key Product Details

Description:	Selective α_1A antagonist
Chemical Name:	5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	444.97

View Full Technical Details for Tamsulosin hydrochloride

Technical Data
Citations (3) / Reviews (1)

Biological Activity for Tamsulosin hydrochloride

Tamsulosin hydrochloride is a selective α_1A-adrenoceptor antagonist (pK_i values are 9.97, 9.64 and 8.86 for α_1A, α_1B and α_1D subtypes respectively). Decreases resting maximal urethral pressure with negligible effect on mean arterial blood pressure in vivo.

Compound Libraries for Tamsulosin hydrochloride

Tamsulosin hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Tamsulosin hydrochloride

M. Wt	444.97
Formula	C₂₀H₂₈N₂O₅S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	106463-17-6
PubChem ID	5362376
InChi Key	ZZIZZTHXZRDOFM-XFULWGLBSA-N
Smiles	C[C@@H](NCCOC2=CC=CC=C2OCC)CC1=CC=C(OC)C(S(=O)(N)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tamsulosin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	4.45	10
	DMSO	44.5	100

Preparing Stock Solutions for Tamsulosin hydrochloride

The following data is based on the product molecular weight 444.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.24 mL	22.47 mL
5 mM	0.45 mL	2.25 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.25 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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Reconstitution Calculator

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References for Tamsulosin hydrochloride

References are publications that support the biological activity of the product.

Ohtake Effects of tamsu. on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 2005 PMID: 16536901
Taguchi Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 1997 PMID: 8996174
Garcia-Sainz Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 1995 PMID: 7781702

Citations for Tamsulosin hydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for Tamsulosin hydrochloride include:

Xiao et al. (2019) Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system. Commun Biol. 2:33
PMID: 30701198
Kunit et al. (2014) Inhibition of smooth muscle force generation by focal adhesion kinase inhibitors in the hyperplastic human prostate. Am J Physiol Renal Physiol. 307:F823
PMID: 25056351
Trevisani et al. (2005) Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways. Br J Pharmacol. 145:1123
PMID: 15937520

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Customer Reviews for Tamsulosin hydrochloride (1)

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Used to investigate cell metabolism

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: Primary hippocampal neurons

The drug was incubated at 10 μM to investigate a potential effect on cell metabolism.

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