Tamsulosin hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3050
Selective α1A antagonist
Key Product Details
Description
Selective α1A antagonist
Product Description
Tamsulosin hydrochloride is a selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligible effect on mean arterial blood pressure in vivo.Product Specifications
Molecular Weight
444.97
Formula
C20H28N2O5S.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
CAS Number
106463-17-6
PubChem ID
5362376
InChI Key
ZZIZZTHXZRDOFM-XFULWGLBSA-N
SMILES
C[C@@H](NCCOC2=CC=CC=C2OCC)CC1=CC=C(OC)C(S(=O)(N)=O)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.45 | 10 | |
| DMSO | 44.5 | 100 |
Preparing Stock Solutions
for Tamsulosin hydrochloride
The following data is based on the product molecular weight 444.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.24 mL | 22.47 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.25 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Taguchi Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 1997 PMID: 8996174
- Ohtake Effects of tamsu. on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 2005 PMID: 16536901
- Garcia-Sainz Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 1995 PMID: 7781702
Product Specific Notices for Tamsulosin hydrochloride
For research use only
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