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Key Product Details
| Description: | α1 and α2B antagonist; also MT3 antagonist |
| Chemical Name: | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride |
| Purity: | ≥99% (HPLC) |
| Molecular Weight: | 419.87 |
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Citations (12)
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Citations are publications that use Bio-Techne products. Selected citations for Prazosin hydrochloride include:
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Kahn et al.
(2016)
The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
EMBO Mol Med.
8:511
PMID: 27138566 -
Delaney and Crane
(2016)
Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels.
Sci Rep.
6:19255
PMID: 26755335 -
Corcoran et al.
(2014)
Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
Pain.
34:51
PMID: 24381267 -
Skelly and Weiner
(2014)
Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
Brain Behav.
4:468
PMID: 25161814 -
Hughes et al.
(2013)
Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
J Clin Invest.
154:1680
PMID: 23707289 -
Zemkova et al.
(2011)
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Endocrinology.
152:3842
PMID: 21828176 -
Tjen-A-Looi et al.
(2011)
Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats.
Am J Physiol Heart Circ Physiol.
300:H1003
PMID: 21217073 -
Ajmo et al.
(2009)
Blockade of adrenoreceptors inhibits the splenic response to stroke.
Cell Rep.
218:47
PMID: 19371742 -
Huang et al.
(2009)
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Neuropsychopharmacology.
34:1979
PMID: 19212317 -
Zhu et al.
(2007)
Tyramine excites rat subthalamic neurons in vitro by a DA-dependent mechanism.
Neuropharmacology.
52:1169
PMID: 17291545 -
Moura et al.
(2006)
Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.
Br J Pharmacol.
149:1049
PMID: 17075569 -
Sjöblom et al.
(2001)
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
Exp Neurol.
108:625
PMID: 11518737
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