Prazosin hydrochloride

Name: Prazosin hydrochloride
Brand: Tocris Bioscience
SKU: 0623

Tocris Bioscience a Bio-Techne Brand

Catalog # 0623

Citations (12)

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Key Product Details

Description:	α₁ and α_2B antagonist; also MT₃ antagonist
Chemical Name:	1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	419.87

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Biological Activity for Prazosin hydrochloride

Prazosin hydrochloride is an α₁ and α_2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT₃ receptor (K_i = 10.2 nM). In prostate cancer cells, Prazosin induces DNA damage stress, Cdk1 inactivation, G₂ checkpoint arrest and apoptosis. In mice bearing prostate cancer xenografts, oral administration of Prazosin reduces tumor mass.

Compound Libraries for Prazosin hydrochloride

Prazosin hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Prazosin hydrochloride

M. Wt	419.87
Formula	C₁₉H₂₁N₅O₄.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	19237-84-4
PubChem ID	68546
InChi Key	WFXFYZULCQKPIP-UHFFFAOYSA-N
Smiles	Cl.COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Prazosin hydrochloride

	Solvent	Max Conc. mM
Solubility
	DMSO	25
	ethanol	5

Preparing Stock Solutions for Prazosin hydrochloride

The following data is based on the product molecular weight 419.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.53 mL	47.63 mL	95.27 mL
1.25 mM	1.91 mL	9.53 mL	19.05 mL
2.5 mM	0.95 mL	4.76 mL	9.53 mL
12.5 mM	0.19 mL	0.95 mL	1.91 mL

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References for Prazosin hydrochloride

References are publications that support the biological activity of the product.

Lin Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia 2007 PMID: 17971903
Paul Characterisation of 2-[¹²⁵I]iodomelatonin binding sites in syrian hamster peripheral organs. J.Pharmacol.Exp.Ther. 1999 PMID: 10381796
Mathe Prazosin inhibits MK-801-induced hyperlocomotion and DA release in the nucleus accumbens. Eur.J.Pharmacol. 1996 PMID: 8864686
Pickering and Niles Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur.J.Pharmacol. 1990 PMID: 2157597

Citations for Prazosin hydrochloride (12)

Showing 1 - 10 of 12 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Prazosin hydrochloride include:

Delaney and Crane (2016) Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep. 6:19255
PMID: 26755335
Kahn et al. (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med. 8:511
PMID: 27138566
Corcoran et al. (2014) Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. Pain. 34:51
PMID: 24381267
Skelly and Weiner (2014) Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav. 4:468
PMID: 25161814
Hughes et al. (2013) Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. J Clin Invest. 154:1680
PMID: 23707289
Zemkova et al. (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca²⁺. Endocrinology. 152:3842
PMID: 21828176
Tjen-A-Looi et al. (2011) Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats. Am J Physiol Heart Circ Physiol. 300:H1003
PMID: 21217073
Ajmo et al. (2009) Blockade of adrenoreceptors inhibits the splenic response to stroke. Cell Rep. 218:47
PMID: 19371742
Huang et al. (2009) Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. Neuropsychopharmacology. 34:1979
PMID: 19212317
Zhu et al. (2007) Tyramine excites rat subthalamic neurons in vitro by a DA-dependent mechanism. Neuropharmacology. 52:1169
PMID: 17291545
Moura et al. (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol. 149:1049
PMID: 17075569
Sjöblom et al. (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. Exp Neurol. 108:625
PMID: 11518737

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