Cirazoline hydrochloride

Name: Cirazoline hydrochloride
Brand: Tocris Bioscience
SKU: 0888

Catalog # 0888

Citations (4)

COA / SDS

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Key Product Details

Description:	Selective α₁ agonist
Chemical Name:	2-(2-Cyclopropylphenoxymethyl)imidazoline hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	252.74

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Biological Activity

Cirazoline hydrochloride is a selective α₁ agonist.

Technical Data

M. Wt	252.74
Formula	C₁₃H₁₆N₂O.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	40600-13-3
PubChem ID	11957512
InChi Key	XFRXWLWUUDJHPB-UHFFFAOYSA-N
Smiles	Cl.C(OC1=C(C=CC=C1)C1CC1)C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.27	100
	DMSO	25.27	100

Preparing Stock Solutions

The following data is based on the product molecular weight 252.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.96 mL	19.78 mL	39.57 mL
5 mM	0.79 mL	3.96 mL	7.91 mL
10 mM	0.40 mL	1.98 mL	3.96 mL
50 mM	0.08 mL	0.40 mL	0.79 mL

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References

References are publications that support the biological activity of the product.

Le Rouzic Binding of [³H]cirazoline to an imidazoline site in rat brain and kidney membranes. Eur.J.Pharmacol. 1995 PMID: 7589165
Wikberg and Uklen Further characterisation of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug. J.Neurochem. 1990 PMID: 1972387
Gellai and Ruffolo Renal effects of selective alpha-1 and alpha-2 adrenoreceptor agonists in conscious normotensive rats. J.Pharmacol.Exp.Ther. 1987 PMID: 2882013

Citations for Cirazoline hydrochloride (4)

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Citations are publications that use Bio-Techne products. Selected citations for Cirazoline hydrochloride include:

Montgomery (2017) An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice. Plos One. 12:e0168409
PMID: 28081170
Kahn et al. (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med. 8:511
PMID: 27138566
Bhattachariya et al. (2014) PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle. Physiol Rep. 2
PMID: 25347863
Maupoil et al. (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol. 150:899
PMID: 17325650

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