BAY 6096

Name: BAY 6096
Brand: Tocris Bioscience
SKU: 8006

Tocris Bioscience, part of Bio-Techne | Catalog # 8006

COA / SDS

Potent and selective adrenergic α2B antagonist

Key Product Details

Description:	Potent and selective adrenergic α_2B antagonist
Chemical Name:	1-[2-[[[3-(3,5-Dimethyl-4-isoxazolyl)imidazo[1,2-a]pyridin-7-yl]carbonyl]amino]ethyl]-4-(methylamino)pyridinium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	426.91

View Full Technical Details for BAY 6096

Technical Data
Citations

Biological Activity for BAY 6096

BAY 6096 is a potent (IC₅₀ = 14 nM), and selective adrenergic α_2B receptor antagonist that displays 394, 725, >845-fold selectivity over α_1A, α_2A, and α_2C, respectively. BAY 6096 reduces α_2B receptor agonist-induced vasoconstriction and has a high clearance and low mean residence times in rats. BAY 6096 is highly water-soluble.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 6096 probe summary on the SGC website.

Technical Data for BAY 6096

M. Wt	426.91
Formula	C₂₁H₂₃ClN₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2313483-41-7
PubChem ID	153534231
InChi Key	HVVLGXULBVAFRZ-UHFFFAOYSA-N
Smiles	O=C(C1=CC2=NC=C(C3=C(C)ON=C3C)N2C=C1)NCC[N+]4=CC=C(NC)C=C4.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 6096

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	42.69	100
	DMSO	42.69	100

Preparing Stock Solutions for BAY 6096

The following data is based on the product molecular weight 426.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.71 mL	23.42 mL
5 mM	0.47 mL	2.34 mL	4.68 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for BAY 6096

References are publications that support the biological activity of the product.

Meibom BAY-6096: A potent, selective, and highly water-soluble adrenergic a2B antagonist. J Med Chem 2023 PMID: 36932954