BAY 6096
Tocris Bioscience, part of Bio-Techne | Catalog # 8006
Potent and selective adrenergic α2B antagonist
Key Product Details
Description
Potent and selective adrenergic α2B antagonist
Product Description
BAY 6096 is a potent (IC50 = 14 nM), and selective adrenergic α2B receptor antagonist that displays 394, 725, >845-fold selectivity over α1A, α2A, and α2C, respectively. BAY 6096 reduces α2B receptor agonist-induced vasoconstriction and has a high clearance and low mean residence times in rats. BAY 6096 is highly water-soluble.Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 6096 probe summary on the SGC website.Product Specifications
Molecular Weight
426.91
Formula
C21H23ClN6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[2-[[[3-(3,5-Dimethyl-4-isoxazolyl)imidazo[1,2-a]pyridin-7-yl]carbonyl]amino]ethyl]-4-(methylamino)pyridinium chloride
CAS Number
2313483-41-7
PubChem ID
153534231
InChI Key
HVVLGXULBVAFRZ-UHFFFAOYSA-N
SMILES
O=C(C1=CC2=NC=C(C3=C(C)ON=C3C)N2C=C1)NCC[N+]4=CC=C(NC)C=C4.[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 42.69 | 100 | |
| DMSO | 42.69 | 100 |
Preparing Stock Solutions
for BAY 6096
The following data is based on the product molecular weight 426.91
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.71 mL | 23.42 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Meibom BAY-6096: A potent, selective, and highly water-soluble adrenergic a2B antagonist. J Med Chem 2023 PMID: 36932954
Product Specific Notices for BAY 6096
For research use only
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