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Additional RTK Inhibitors: Small Molecules and Peptides

23 results for "Additional RTK Inhibitors Small Molecules and Peptides" in Products

23 results for "Additional RTK Inhibitors Small Molecules and Peptides" in Products

Additional RTK Inhibitors: Small Molecules and Peptides

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

Alternate Names: Semaxinib
Chemical Name: 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
Purity: ≥98% (HPLC)
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea
Purity: ≥97% (HPLC)
c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

Potent Mer kinase inhibitor

Chemical Name: 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Potent Mer kinase inhibitor

Potent VEGFR, PDGFRβ and KIT inhibitor

Alternate Names: SU 11248
Chemical Name: N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt
Purity: ≥98% (HPLC)
Potent VEGFR, PDGFRβ and KIT inhibitor

Potent and selective DDR1 inhibitor; orally bioavailable

Chemical Name: 4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
Purity: ≥98% (HPLC)
Potent and selective DDR1 inhibitor; orally bioavailable

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Chemical Name: 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine
Purity: ≥98% (HPLC)
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Potent Tie2 inhibitor

Chemical Name: [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
Purity: ≥98% (HPLC)
Potent Tie2 inhibitor

Potent and selective RET inhibitor

Chemical Name: 6-(2-Hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
Purity: ≥98% (HPLC)
Potent and selective RET inhibitor

Selective cFMS kinase inhibitor; orally bioavailable

Chemical Name: 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Selective cFMS kinase inhibitor; orally bioavailable

Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R

Chemical Name: N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Purity: ≥98% (HPLC)
Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R

Zap70 inhibitor; inhibits interaction with ITAMs

Chemical Name: 5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Zap70 inhibitor; inhibits interaction with ITAMs

Potent and selective discoidin domain receptor 1/2 inhibitor

Chemical Name: 4-Fluoro-3-[[[5-(1-methyl-1H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
Purity: ≥98% (HPLC)
Potent and selective discoidin domain receptor 1/2 inhibitor

Dual Mer/Axl inhibitor

Chemical Name: 3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine
Purity: ≥97% (HPLC)
Mer/Axl Dual inhibitor

Potent CSF-1R inhibitor

Chemical Name: N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Purity: ≥98% (HPLC)
Potent CSF-1R inhibitor

Selective DDR1 inhibitor

Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
Purity: ≥98% (HPLC)
Selective DDR1 inhibitor

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

Chemical Name: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
Purity: ≥98% (HPLC)
Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

Potent VEGFR inhibitor; also inhibits other RTKs

Alternate Names: Cabozantinib,BMS 907351
Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Purity: ≥98% (HPLC)
Potent VEGFR inhibitor; also inhibits other RTKs

Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

Chemical Name: cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol
Purity: ≥98% (HPLC)
Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

Potent and selective FGFR inhibitor

Chemical Name: rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
Purity: ≥98% (HPLC)
Potent and selective FGFR inhibitor

Potent and selective PDGFR family inhibitor

Chemical Name: N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
Purity: ≥98% (HPLC)
Potent and selective PDGFR family inhibitor

Potent RET inhibitor

Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Potent RET inhibitor

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Chemical Name: 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Purity: ≥98% (HPLC)
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons

Chemical Name: 4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzeneacetamide
Purity: ≥98% (HPLC)
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons
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