GW 2580
Tocris Bioscience, part of Bio-Techne | Catalog # 5673
Selective cFMS kinase inhibitor; orally bioavailable
Key Product Details
Description
Selective cFMS kinase inhibitor; orally bioavailable
Product Description
GW 2580 is a potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.Product Specifications
Molecular Weight
366.41
Formula
C20H22N4O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine
CAS Number
870483-87-7
PubChem ID
11617559
InChI Key
MYQAUKPBNJWPIE-UHFFFAOYSA-N
SMILES
NC1=C(CC2=CC(OC)=C(OCC3=CC=C(OC)C=C3)C=C2)C=NC(N)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.32 | 50 |
Preparing Stock Solutions
for GW 2580
The following data is based on the product molecular weight 366.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.46 mL | 27.29 mL | 54.58 mL |
| 2.5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 25 mM | 0.11 mL | 0.55 mL | 1.09 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Conway Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J.Pharmacol.Exp.Ther. 2008 PMID: 18434589
- Conway Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc.Natl.Acad.Sci.U.S.A. 2005 PMID: 16249345
Product Specific Notices for GW 2580
For research use only
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