GW 2580

Name: GW 2580
Brand: Tocris Bioscience
SKU: 5673

Tocris Bioscience a Bio-Techne Brand

Catalog # 5673

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Key Product Details

Description:	Selective cFMS kinase inhibitor; orally bioavailable
Chemical Name:	5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine
Purity:	≥99% (HPLC)
Molecular Weight:	366.41

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Biological Activity for GW 2580

GW 2580 is a potent and selective cFMS kinase inhibitor (IC₅₀ = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.

Technical Data for GW 2580

M. Wt	366.41
Formula	C₂₀H₂₂N₄O₃
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	870483-87-7
PubChem ID	11617559
InChi Key	MYQAUKPBNJWPIE-UHFFFAOYSA-N
Smiles	NC1=C(CC2=CC(OC)=C(OCC3=CC=C(OC)C=C3)C=C2)C=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 2580

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.32	50

Preparing Stock Solutions for GW 2580

The following data is based on the product molecular weight 366.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.46 mL	27.29 mL	54.58 mL
2.5 mM	1.09 mL	5.46 mL	10.92 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
25 mM	0.11 mL	0.55 mL	1.09 mL

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References for GW 2580

References are publications that support the biological activity of the product.

Conway Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J.Pharmacol.Exp.Ther. 2008 PMID: 18434589
Conway Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc.Natl.Acad.Sci.U.S.A. 2005 PMID: 16249345

Citations for GW 2580

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