VU 6015929
Tocris Bioscience, part of Bio-Techne | Catalog # 7728
Potent and selective discoidin domain receptor 1/2 inhibitor
Key Product Details
Description
Potent and selective discoidin domain receptor 1/2 inhibitor
Product Description
VU 6015929 is a potent and selective discoidin domain receptor 1/2 (DDR1/2) inhibitor (IC50 = 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively). VU 6015929 blocks collagen-induced DDR1 activation and collagen-IV production in HEK293 cells.Product Specifications
Molecular Weight
485.43
Formula
C24H19F4N5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Fluoro-3-[[[5-(1-methyl-1H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
CAS Number
2442597-56-8
PubChem ID
145925694
InChI Key
IZKVIUJIUTXIRH-UHFFFAOYSA-N
SMILES
O=C(NC=1C=CC=C(OC(F)(F)F)C1)C2=CC=C(F)C(=C2)NCC3=CN=CC(=C3)C4=NN(C=C4)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.54 | 100 | |
| Ethanol | 9.71 | 20 |
Preparing Stock Solutions
for VU 6015929
The following data is based on the product molecular weight 485.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.30 mL | 20.60 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jeffries Discovery of VU6015929: a selective discoidin domain receptor 1/2 (DDR1/2) inhibitor to explore the role of DDR1 in antifibrotic therapy. ACS Med.Chem.Lett. 2019 PMID: 31938459
- Sun Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Nature 2021 PMID: 34732895
Product Specific Notices for VU 6015929
For research use only
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